| GOLEADORES CAMPEONATO CLAUSURA 2022 | ||
| Goles | Jugador | Equipo |
| 12 | Lorenzo Melgarejo | Libertad |
| 12 | Derlis Gonzalez | Olimpia |
| 9 | Oscar Cardozo | Libertad |
| 8 | Nildo Viera | Guaireña |
| 8 | Fernando Fernandez | Guarani |
| 8 | Juan Danilo Santacruz | Nacional |
| 7 | Facundo Bruera | Nacional |
| 7 | Ronaldo Martinez | Resistencia |
| 6 | Clementino Gonzalez | General Caballero |
| 6 | Brian Montenegro | Olimpia |
| 6 | Alex Arce | Sportivo Ameliano |
| 5 | Alberto Espinola | Cerro Porteño |
| 5 | Braian Samudio | Cerro Porteño |
| 5 | Roque Santa Cruz | Libertad |
| 5 | Alejandro Silva | Olimpia |
| 5 | Guillermo Paiva | Olimpia |
| 4 | Marcelo Moreno Martins | Cerro Porteño |
| 4 | Nestor Camacho | Guarani |
| 4 | Cristian Duma | Sol de America |
| 4 | Santiago Salcedo | Sol de America |
| 4 | Jorge Sanguina | Sportivo Ameliano |
| 4 | Gustavo Aguilar | Tacuary |
| 4 | Ivan Valdez | Tacuary |
| 4 | Jorge Ortega | Tacuary |
| 3 | Antonio Galeano | Cerro Porteño |
| 3 | Federico Carrizo | Cerro Porteño |
| 3 | Franco Costa | General Caballero |
| 3 | Juan Jose Heinze | General Caballero |
| 3 | Teodoro Sebastian Arce | General Caballero |
| 3 | Cristhian Ocampos | Guaireña |
| 3 | Lautaro Comas | Guaireña |
| 3 | Richard Salinas | Guaireña |
| 3 | Bautista Merlini | Libertad |
| 3 | Gustavo Caballero | Nacional |
| 3 | Richard Ortiz | Olimpia |
| 3 | Alan Pereira | Resistencia |
| 3 | Gianlucca Fatecha | Sol de America |
| 3 | Diego Barreto | Sportivo Ameliano |
| 3 | Elias Sarquis | Sportivo Ameliano |
| 3 | Marcelo Fernandez | Tacuary |
| 2 | Carlos Silva | 12 de Octubre |
| 2 | David Mendieta Chavez | 12 de Octubre |
| 2 | Martin Batallini | 12 de Octubre |
| 2 | Nelson Sanabria | 12 de Octubre |
| 2 | Fernando Romero | Cerro Porteño |
| 2 | Jose Manuel Vera | General Caballero |
| 2 | Leonardo Rolon | General Caballero |
| 2 | Wilder Viera | General Caballero |
| 2 | Cesar Villagra | Guaireña |
| 2 | Miguel Paniagua | Guaireña |
| 2 | Victor Ayala | Guaireña |
| 2 | Alberto Contrera | Guarani |
| 2 | Angel Benitez | Guarani |
| 2 | Marcelo Gonzalez | Guarani |
| 2 | Cristian Riveros | Libertad |
| 2 | Diego Gomez | Libertad |
| 2 | David Fleitas | Nacional |
| 2 | Francisco Morel | Nacional |
| 2 | Rolando Garcia | Nacional |
| 2 | Mateo Gamarra | Olimpia |
| 2 | Resistencia | |
| 2 | Emiliano Ozuna | Sol de America |
| 2 | Tomas Rojas | Sol de America |
| 2 | Victor Barrios | Sol de America |
| 2 | Alejandro Samudio | Sportivo Ameliano |
| 2 | Fredy Vera | Sportivo Ameliano |
| 2 | Nicolas Morinigo | Sportivo Ameliano |
| 2 | Pablo Zeballos | Sportivo Ameliano |
| 2 | Lucas Sanabria | Tacuary |
| 2 | Nery Bareiro | Tacuary |
| 2 | Nestor Gimenez | Tacuary |
| 1 | Dionisio Perez | 12 de Octubre |
| 1 | Elvio Vera | 12 de Octubre |
| 1 | Francisco Manenti | 12 de Octubre |
| 1 | Juan Gomez | 12 de Octubre |
| 1 | Luis Fernandez | 12 de Octubre |
| 1 | Luis Martinez | 12 de Octubre |
| 1 | Marco Gonzalez | 12 de Octubre |
| 1 | Victor Caceres | 12 de Octubre |
| 1 | Alan Cardozo Lucena | Cerro Porteño |
| 1 | Alan Rodriguez | Cerro Porteño |
| 1 | Carlos Rolon | Cerro Porteño |
| 1 | Claudio Aquino | Cerro Porteño |
| 1 | Damian Bobadilla | Cerro Porteño |
| 1 | Fernando Ovelar | Cerro Porteño |
| 1 | Gabriel Baez | Cerro Porteño |
| 1 | Juan Patiño | Cerro Porteño |
| 1 | Robert Piris da Motta | Cerro Porteño |
| 1 | Derlis Martinez | General Caballero |
| 1 | Guillermo Hauche | General Caballero |
| 1 | Jorge Gonzalez | General Caballero |
| 1 | Juan Franco | General Caballero |
| 1 | Orlando Junior Barreto | General Caballero |
| 1 | Feliciano Brizuela | Guaireña |
| 1 | Jose Ariel Nuñez | Guaireña |
| 1 | Rosalino Toledo | Guaireña |
| 1 | Fernando Roman | Guarani |
| 1 | Jorge Mendoza | Guarani |
| 1 | Marcos Caceres | Guarani |
| 1 | Matias Segovia | Guarani |
| 1 | Ivan Piris | Libertad |
| 1 | Rodrigo Bogarin | Libertad |
| 1 | Carlos Arrua | Nacional |
| 1 | Claudio Nuñez | Nacional |
| 1 | Matias Martinez | Nacional |
| 1 | Miguel Jacquet | Nacional |
| 1 | Orlando Gaona Lugo | Nacional |
| 1 | Ruben Dario Rios | Nacional |
| 1 | Fernando Cardozo | Olimpia |
| 1 | Hugo Fernandez | Olimpia |
| 1 | Jorge Recalde | Olimpia |
| 1 | Luis Zarate | Olimpia |
| 1 | Marcos Gomez | Olimpia |
| 1 | Saul Salcedo | Olimpia |
| 1 | Victor Salazar | Olimpia |
| 1 | Walter Gonzalez | Olimpia |
| 1 | Alexis Rojas | Resistencia |
| 1 | Diego Martinez | Resistencia |
| 1 | Juan Recalde | Resistencia |
| 1 | Ruan | Resistencia |
| 1 | Jaime Moreno | Sol de America |
| 1 | Marcelo Estigarribia | Sol de America |
| 1 | Oscar Coronel | Sol de America |
| 1 | Rodrigo Rojas | Sol de America |
| 1 | Edgar Zaracho | Sportivo Ameliano |
| 1 | Jonathan Gomez | Sportivo Ameliano |
| 1 | Emanuel Biancucchi | Tacuary |
| 1 | Ivan Salcedo | Tacuary |
| 1 | Marcelo Paredes | Tacuary |
| 1 | Valdeci | Tacuary |
| Autogoles | ||
| Jugador | Equipo | |
| 1 | Danilo Ortiz | 12 de Octubre |
| 1 | Daniel Bocanegra | Libertad |
| 1 | Jordan Santacruz | Nacional |
| 1 | Rhuan | Resistencia |
| 1 | Sebastian Olmedo | Sol de America |
| 1 | Martin Silva | Sportivo Ameliano |
| 1 | Pablo Aguilar | Sportivo Ameliano |
| 1 | Marcelo Paredes | Tacuary |