| GOLEADORES CAMPEONATO APERTURA 2025 | |||
| Goles | Jugador | Equipo | |
| 7 | Lorenzo Melgarejo | Libertad | |
| 6 | Juan Iturbe | Cerro Porteño | |
| 6 | Fernando Fernandez | Guarani | |
| 5 | Oscar Cardozo | Libertad | |
| 5 | Rodney Redes | Olimpia | |
| 5 | Alejandro Silva | Recoleta | |
| 5 | Juan Manuel Romero | Sportivo Trinidense | |
| 4 | Jonathan Torres | Cerro Porteño | |
| 4 | Gustavo Caballero | Nacional | |
| 4 | Derlis Gonzalez | Olimpia | |
| 4 | Wilfrido Baez | Recoleta | |
| 3 | Federico Carrizo | Cerro Porteño | |
| 3 | Ronald Roa | General Caballero | |
| 3 | Teodoro Sebastian Arce | General Caballero | |
| 3 | Gaspar Servio | Guarani | |
| 3 | Ruben Lezcano | Libertad | |
| 3 | Cristhian Ocampos | Sportivo Ameliano | |
| 3 | Giovanni Bogado | Sportivo Ameliano | |
| 3 | Nestor Camacho | Sportivo Trinidense | |
| 3 | Ronaldo Baez | Sportivo Trinidense | |
| 2 | Diego Acosta | 2 de Mayo | |
| 2 | Ronald Cornet | 2 de Mayo | |
| 2 | Cecilio Dominguez | Cerro Porteño | |
| 2 | William Mendieta | Guarani | |
| 2 | Alexis Fretes | Libertad | |
| 2 | Ivan Franco | Libertad | |
| 2 | Marcelo Fernandez | Libertad | |
| 2 | Matias Espinoza | Libertad | |
| 2 | Roque Santa Cruz | Libertad | |
| 2 | Hugo Fernandez | Olimpia | |
| 2 | Lisandro Lopez | Olimpia | |
| 2 | Hugo Sandoval | Recoleta | |
| 2 | Lucas Gonzalez | Recoleta | |
| 2 | Matias Lopez | Recoleta | |
| 2 | Luis Ortiz | Sportivo Ameliano | |
| 2 | Elvio Vera | Sportivo Luqueño | |
| 2 | Walter Gonzalez | Sportivo Luqueño | |
| 2 | Aaron Spetale | Tembetary | |
| 2 | Rodrigo Lopez | Tembetary | |
| 2 | Willian Candia | Tembetary | |
| 1 | Amin Molinas | 2 de Mayo | |
| 1 | Marcos Caballero | 2 de Mayo | |
| 1 | Oscar Romero | 2 de Mayo | |
| 1 | Pedro Sosa | 2 de Mayo | |
| 1 | Sergio Bareiro | 2 de Mayo | |
| 1 | Alan Benitez | Cerro Porteño | |
| 1 | Victor Gustavo Velazquez | Cerro Porteño | |
| 1 | Clementino Gonzalez | General Caballero | |
| 1 | Cristhian Baez | General Caballero | |
| 1 | Fernando Lesme | General Caballero | |
| 1 | Gabriel Molinas | General Caballero | |
| 1 | Juan Alexander Franco | General Caballero | |
| 1 | Daniel Perez | Guarani | |
| 1 | Diego Fernandez | Guarani | |
| 1 | Alex Campuzano | Libertad | |
| 1 | Gustavo Aguilar | Libertad | |
| 1 | Hugo Martinez | Libertad | |
| 1 | Ivan Ramirez | Libertad | |
| 1 | Nestor Gimenez | Libertad | |
| 1 | Fabian Franco | Nacional | |
| 1 | Juan Cruz Monteagudo | Nacional | |
| 1 | Juan Fernando Alfaro | Nacional | |
| 1 | Juan Luis Alfaro | Nacional | |
| 1 | Tiago Caballero | Nacional | |
| 1 | Alejandro Maciel | Olimpia | |
| 1 | Erik Lopez | Olimpia | |
| 1 | Ivan Leguizamon | Olimpia | |
| 1 | Javier Dominguez | Olimpia | |
| 1 | Lucas Pratto | Olimpia | |
| 1 | Richard Ortiz | Olimpia | |
| 1 | Aldo Gonzalez | Recoleta | |
| 1 | Claudio Garay | Recoleta | |
| 1 | Hernan Perez | Recoleta | |
| 1 | Juan Nuñez | Recoleta | |
| 1 | Junior Noguera | Recoleta | |
| 1 | Miguel Samudio | Recoleta | |
| 1 | Diego Barreto | Sportivo Ameliano | |
| 1 | Estivel Moreira | Sportivo Ameliano | |
| 1 | Fredy Vera | Sportivo Ameliano | |
| 1 | Ivan Valdez | Sportivo Ameliano | |
| 1 | Angel Benitez | Sportivo Luqueño | |
| 1 | Angel Brizuela | Sportivo Luqueño | |
| 1 | Lautaro Comas | Sportivo Luqueño | |
| 1 | Rodrigo Alborno | Sportivo Luqueño | |
| 1 | Wilson Brahian Ayala | Sportivo Luqueño | |
| 1 | Armando Ruiz Diaz | Sportivo Trinidense | |
| 1 | Diego Torres | Sportivo Trinidense | |
| 1 | Luis de la Cruz | Sportivo Trinidense | |
| 1 | Nelson Ariel Gauto | Sportivo Trinidense | |
| 1 | Oscar Gimenez | Sportivo Trinidense | |
| 1 | Alan Paredes | Tembetary | |
| 1 | Estiven Omar Perez | Tembetary | |
| 1 | Jorge Nuñez | Tembetary | |
| 1 | Nicolas Malvacio | Tembetary | |
| Autogoles | |||
| Jugador | Equipo | ||
| 1 | Jesus Abel Paredes | Olimpia | |
| 1 | Alexis Rodas | General Caballero | |
| 1 | Angel Espinola | Tembetary | |
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