| GOLEADORES CAMPEONATO APERTURA 2025 | ||
| Goles | Jugador | Equipo |
| 9 | Juan Iturbe | Cerro Porteño |
| 9 | Gustavo Caballero | Nacional |
| 8 | Fernando Fernandez | Guarani |
| 7 | Lorenzo Melgarejo | Libertad |
| 6 | Jonathan Torres | Cerro Porteño |
| 6 | Teodoro Sebastian Arce | General Caballero |
| 6 | Rodney Redes | Olimpia |
| 6 | Alejandro Silva | Recoleta |
| 6 | Juan Manuel Romero | Sportivo Trinidense |
| 6 | Nestor Camacho | Sportivo Trinidense |
| 5 | Sergio Araujo | Cerro Porteño |
| 5 | Diego Fernandez | Guarani |
| 5 | Oscar Cardozo | Libertad |
| 5 | Ivan Leguizamon | Olimpia |
| 5 | Ivan Valdez | Sportivo Ameliano |
| 4 | Sergio Bareiro | 2 de Mayo |
| 4 | Federico Carrizo | Cerro Porteño |
| 4 | Matias Espinoza | Libertad |
| 4 | Derlis Gonzalez | Olimpia |
| 4 | Hugo Sandoval | Recoleta |
| 4 | Wilfrido Baez | Recoleta |
| 3 | Alan Benitez | Cerro Porteño |
| 3 | Cecilio Dominguez | Cerro Porteño |
| 3 | Clementino Gonzalez | General Caballero |
| 3 | Ronald Roa | General Caballero |
| 3 | Gaspar Servio | Guarani |
| 3 | Richard Torales | Guarani |
| 3 | Ruben Lezcano | Libertad |
| 3 | Carlos Arrua | Nacional |
| 3 | Lucas Gonzalez | Recoleta |
| 3 | Cristhian Ocampos | Sportivo Ameliano |
| 3 | Giovanni Bogado | Sportivo Ameliano |
| 3 | Luis Ortiz | Sportivo Ameliano |
| 3 | Walter Gonzalez | Sportivo Luqueño |
| 3 | Ronaldo Baez | Sportivo Trinidense |
| 3 | Aaron Spetale | Tembetary |
| 3 | Estiven Omar Perez | Tembetary |
| 3 | Willian Candia | Tembetary |
| 2 | Diego Acosta | 2 de Mayo |
| 2 | Ronald Cornet | 2 de Mayo |
| 2 | Juan Alexander Franco | General Caballero |
| 2 | Agustin Manzur | Guarani |
| 2 | William Mendieta | Guarani |
| 2 | Alex Campuzano | Libertad |
| 2 | Alexis Fretes | Libertad |
| 2 | Ivan Franco | Libertad |
| 2 | Marcelo Fernandez | Libertad |
| 2 | Roque Santa Cruz | Libertad |
| 2 | Richard Prieto | Nacional |
| 2 | Tiago Caballero | Nacional |
| 2 | Hugo Fernandez | Olimpia |
| 2 | Lisandro Lopez | Olimpia |
| 2 | Matias Lopez | Recoleta |
| 2 | Elvio Vera | Sportivo Luqueño |
| 2 | Estifen Diaz | Sportivo Trinidense |
| 2 | Joel Roman | Sportivo Trinidense |
| 2 | Rodrigo Lopez | Tembetary |
| 1 | Amin Molinas | 2 de Mayo |
| 1 | Fernando Ruiz Diaz | 2 de Mayo |
| 1 | Jesus Llano | 2 de Mayo |
| 1 | Marcos Caballero | 2 de Mayo |
| 1 | Orlando Colman | 2 de Mayo |
| 1 | Oscar Romero | 2 de Mayo |
| 1 | Pedro Sosa | 2 de Mayo |
| 1 | Diego Leon | Cerro Porteño |
| 1 | Ricardo Marecos | Cerro Porteño |
| 1 | Victor Gustavo Velazquez | Cerro Porteño |
| 1 | Cristhian Baez | General Caballero |
| 1 | Fernando Lesme | General Caballero |
| 1 | Gabriel Molinas | General Caballero |
| 1 | Jorge Gonzalez | General Caballero |
| 1 | Osmar Gimenez | General Caballero |
| 1 | Alan Romero | Guarani |
| 1 | Alex Cantero | Guarani |
| 1 | Daniel Perez | Guarani |
| 1 | Ivan Ramirez | Guarani |
| 1 | Gustavo Aguilar | Libertad |
| 1 | Hernesto Caballero | Libertad |
| 1 | Hugo Martinez | Libertad |
| 1 | Ivan Ramirez | Libertad |
| 1 | Lucas Sanabria | Libertad |
| 1 | Nestor Gimenez | Libertad |
| 1 | Cristian Colman | Nacional |
| 1 | Fabian Franco | Nacional |
| 1 | Juan Cruz Monteagudo | Nacional |
| 1 | Juan Fernando Alfaro | Nacional |
| 1 | Juan Luis Alfaro | Nacional |
| 1 | Orlando Gaona | Nacional |
| 1 | Alan Morinigo | Olimpia |
| 1 | Alejandro Maciel | Olimpia |
| 1 | Erik Lopez | Olimpia |
| 1 | Facundo Zabala | Olimpia |
| 1 | Javier Dominguez | Olimpia |
| 1 | Lucas Pratto | Olimpia |
| 1 | Luis Abreu | Olimpia |
| 1 | Richard Ortiz | Olimpia |
| 1 | Aldo Gonzalez | Recoleta |
| 1 | Claudio Garay | Recoleta |
| 1 | Facundo Echeguren | Recoleta |
| 1 | Hector Lopez | Recoleta |
| 1 | Hernan Perez | Recoleta |
| 1 | Juan Nuñez | Recoleta |
| 1 | Junior Noguera | Recoleta |
| 1 | Miguel Samudio | Recoleta |
| 1 | Aaron Paez | Sportivo Ameliano |
| 1 | Alejandro Samudio | Sportivo Ameliano |
| 1 | Allam Wlk | Sportivo Ameliano |
| 1 | Diego Barreto | Sportivo Ameliano |
| 1 | Elias Sarquis | Sportivo Ameliano |
| 1 | Estivel Moreira | Sportivo Ameliano |
| 1 | Fredy Vera | Sportivo Ameliano |
| 1 | Pablo Aranda | Sportivo Ameliano |
| 1 | Sergio Fretes | Sportivo Ameliano |
| 1 | Angel Benitez | Sportivo Luqueño |
| 1 | Angel Brizuela | Sportivo Luqueño |
| 1 | Julian Marchio | Sportivo Luqueño |
| 1 | Kevin Pereira | Sportivo Luqueño |
| 1 | Lautaro Comas | Sportivo Luqueño |
| 1 | Rodrigo Alborno | Sportivo Luqueño |
| 1 | Rodrigo Caceres | Sportivo Luqueño |
| 1 | Wilson Brahian Ayala | Sportivo Luqueño |
| 1 | Alex Alvarez | Sportivo Trinidense |
| 1 | Armando Ruiz Diaz | Sportivo Trinidense |
| 1 | Axel Cañete | Sportivo Trinidense |
| 1 | Diego Torres | Sportivo Trinidense |
| 1 | Luis de la Cruz | Sportivo Trinidense |
| 1 | Nelson Ariel Gauto | Sportivo Trinidense |
| 1 | Oscar Gimenez | Sportivo Trinidense |
| 1 | Rodrigo Arevalo | Sportivo Trinidense |
| 1 | Alan Paredes | Tembetary |
| 1 | Jorge Nuñez | Tembetary |
| 1 | Nicolas Malvacio | Tembetary |
| 1 | Orlin Barreto | Tembetary |
| 1 | Rodrigo Rojas | Tembetary |
| Autogoles | ||
| Jugador | Equipo | |
| 1 | Alexis Rodas | General Caballero |
| 1 | Jesus Abel Paredes | Olimpia |
| 1 | Sebastian Maldonado | Sportivo Luqueño |
| 1 | Angel Espinola | Tembetary |