| GOLEADORES CAMPEONATO APERTURA 2022 | ||
| Goles | Jugador | Equipo |
| 13 | Fernando Fernandez | Guarani |
| 12 | Facundo Bruera | Nacional |
| 11 | Julio Enciso | Libertad |
| 8 | Alfio Oviedo | Cerro Porteño |
| 8 | Robert Morales | Cerro Porteño |
| 8 | Junior Marabel | General Caballero |
| 8 | Guillermo Paiva | Olimpia |
| 7 | Roque Santa Cruz | Libertad |
| 7 | Alejandro Silva | Olimpia |
| 7 | Walter Gonzalez | Olimpia |
| 6 | Lorenzo Melgarejo | Libertad |
| 6 | Derlis Gonzalez | Olimpia |
| 6 | Diego Martinez | Resistencia |
| 6 | Ronaldo Martinez | Resistencia |
| 5 | Claudio Aquino | Cerro Porteño |
| 5 | Jose Verdun | Sol de America |
| 5 | Ivan Valdez | Tacuary |
| 4 | Guillermo Hauche | General Caballero |
| 4 | Hector Villalba | Libertad |
| 4 | Juan Danilo Santacruz | Nacional |
| 4 | Richard Prieto | Nacional |
| 4 | Pablo Palacios | Resistencia |
| 4 | Antonio Oviedo | Sportivo Ameliano |
| 4 | Jorge Sanguina | Sportivo Ameliano |
| 3 | Ronald Roa | 12 de Octubre |
| 3 | Clementino Gonzalez | General Caballero |
| 3 | Santiago Salcedo | General Caballero |
| 3 | Diego Godoy | Guaireña |
| 3 | Mario Otazu | Guaireña |
| 3 | Alberto Contrera | Guarani |
| 3 | Bautista Merlini | Libertad |
| 3 | Oscar Cardozo | Libertad |
| 3 | William Mendieta | Libertad |
| 3 | David Fleitas | Nacional |
| 3 | Hugo Quintana | Olimpia |
| 3 | Nestor Camacho | Olimpia |
| 3 | Alex Arce | Sportivo Ameliano |
| 3 | Jorge Caceres | Sportivo Ameliano |
| 3 | Marcelo Fernandez | Tacuary |
| 2 | Jorge Gonzalez | 12 de Octubre |
| 2 | Julio Sebastian Doldan | 12 de Octubre |
| 2 | Martin Batallini | 12 de Octubre |
| 2 | Alan Rodriguez | Cerro Porteño |
| 2 | Carlos Rolon | Cerro Porteño |
| 2 | Fernando Romero | Cerro Porteño |
| 2 | Luis Fariña | Cerro Porteño |
| 2 | Marcelo Moreno Martins | Cerro Porteño |
| 2 | Sergio Diaz | Cerro Porteño |
| 2 | Antony Alonso | Guaireña |
| 2 | Carlos Duarte | Guaireña |
| 2 | Richard Salinas | Guaireña |
| 2 | Yeiber Murillo | Guaireña |
| 2 | Bernardo Benitez | Guarani |
| 2 | Marcos Caceres | Guarani |
| 2 | Jorge Recalde | Olimpia |
| 2 | Jorge Gonzalez | Resistencia |
| 2 | Mateo Bustos | Resistencia |
| 2 | Oscar Brizuela | Resistencia |
| 2 | Rodrigo Ruiz Diaz | Resistencia |
| 2 | Enrique Borja | Sol de America |
| 2 | Ivan Cazal | Sol de America |
| 2 | Marcelo Estigarribia | Sol de America |
| 2 | Rodrigo Rojas | Sol de America |
| 2 | Diego Barreto | Sportivo Ameliano |
| 2 | Elias Sarquis | Sportivo Ameliano |
| 2 | Gustavo Caballero | Sportivo Ameliano |
| 2 | Pablo Zeballos | Sportivo Ameliano |
| 2 | Cristhian Ocampos | Tacuary |
| 2 | Lucas Sanabria | Tacuary |
| 1 | Aldo Vera | 12 de Octubre |
| 1 | Danilo Ortiz | 12 de Octubre |
| 1 | David Mendieta Chavez | 12 de Octubre |
| 1 | Jose Maria Ortigoza | 12 de Octubre |
| 1 | Nelson Sanabria | 12 de Octubre |
| 1 | Alberto Espinola | Cerro Porteño |
| 1 | Antonio Galeano | Cerro Porteño |
| 1 | Enzo Gimenez | Cerro Porteño |
| 1 | Rodrigo Delvalle | Cerro Porteño |
| 1 | Giovanni Bordon | General Caballero |
| 1 | Jose Manuel Vera | General Caballero |
| 1 | Juan Franco | General Caballero |
| 1 | Manuel Romero | General Caballero |
| 1 | Orlando Junior Barreto | General Caballero |
| 1 | Aquilino Gimenez | Guaireña |
| 1 | Cesar Villagra | Guaireña |
| 1 | Miguel Paniagua | Guaireña |
| 1 | Milton Maciel | Guaireña |
| 1 | Nelson Ruiz | Guaireña |
| 1 | Victor Barrios | Guaireña |
| 1 | Alejandro Samudio | Guarani |
| 1 | Jorge Mendoza | Guarani |
| 1 | Juan Colman | Guarani |
| 1 | Julio Gonzalez | Guarani |
| 1 | Marcelo Gonzalez | Guarani |
| 1 | Matias Segovia | Guarani |
| 1 | Milciades Adorno | Guarani |
| 1 | Roberto Fernandez | Guarani |
| 1 | Rodi Ferreira | Guarani |
| 1 | Sergio Bareiro | Guarani |
| 1 | Adrian Alcaraz | Libertad |
| 1 | Alex Campuzano | Libertad |
| 1 | Alexander Barboza | Libertad |
| 1 | Cristian Riveros | Libertad |
| 1 | Diego Viera | Libertad |
| 1 | Luis Cardozo | Libertad |
| 1 | Ramon Martinez | Libertad |
| 1 | Rodrigo Bogarin | Libertad |
| 1 | Carlos Arrua | Nacional |
| 1 | Carlos Nuñez | Nacional |
| 1 | Juan Franco | Nacional |
| 1 | Rodrigo Vera | Nacional |
| 1 | Fernando Cardozo | Olimpia |
| 1 | Ivan Torres | Olimpia |
| 1 | Nestor Gimenez | Olimpia |
| 1 | Sergio Otalvaro | Olimpia |
| 1 | Aldo Gonzalez | Resistencia |
| 1 | Fernando Martinez | Resistencia |
| 1 | Ivan Paniagua | Resistencia |
| 1 | Jesus Araujo | Resistencia |
| 1 | Diego Valdez | Sol de America |
| 1 | Emiliano Ozuna | Sol de America |
| 1 | Jorge Aguilar | Sol de America |
| 1 | Nicolas Benegas | Sol de America |
| 1 | Nildo Viera | Sol de America |
| 1 | Cristian Gaitan | Sportivo Ameliano |
| 1 | Junior Vargas | Sportivo Ameliano |
| 1 | Walter Cabrera | Sportivo Ameliano |
| 1 | Elvio Vera | Tacuary |
| 1 | Lucas Gonzalez | Tacuary |
| 1 | Nery Bareiro | Tacuary |
| 1 | Pablo Espinoza | Tacuary |
| Autogoles | ||
| Jugador | Equipo | |
| 1 | Osmar Molinas | 12 de Octubre |
| 1 | Victor Davalos | 12 de Octubre |
| 1 | Joel Jimenez | Guaireña |
| 1 | Jordan Santacruz | Guaireña |
| 1 | Julio Gonzalez | Guarani |
| 1 | Lorenzo Melgarejo | Libertad |
| 1 | Claudio Nuñez | Nacional |
| 1 | Matias Duffard | Resistencia |
| 1 | Oscar Brizuela | Resistencia |
| 1 | Miguel Jacquet | Sol de America |
| 1 | Walter Cabrera | Sportivo Ameliano |
| 1 | Nestor Gimenez | Tacuary |
| 1 | Pablo Espinoza | Tacuary |