| GOLEADORES CAMPEONATO CLAUSURA 2021 | ||
| Goles | Jugador | Equipo |
| 14 | Alexis Canelo | Toluca |
| 11 | Jonathan Rodriguez | Cruz Azul |
| 10 | Santiago Ormeño | Puebla |
| 10 | Nicolas Ibañez | San Luis |
| 9 | Rogerio Funes Mori | Monterrey |
| 8 | Henry Martin | America |
| 8 | Angel Mena | Leon |
| 8 | Eduardo Aguirre | Santos |
| 8 | Fidel Martinez | Tijuana |
| 7 | Victor Davila | Leon |
| 7 | Michael Estrada | Toluca |
| 6 | Roger Martinez | America |
| 6 | Jose Macias | Guadalajara |
| 6 | Roberto de la Rosa | Pachuca |
| 6 | Angel Sepulveda | Queretaro |
| 6 | Nicolas Lopez | Tigres |
| 5 | Dario Lezcano | Juarez |
| 5 | Camilo Sanvezzo | Mazatlan |
| 5 | Maximiliano Meza | Monterrey |
| 5 | Vincent Janssen | Monterrey |
| 5 | Mauro Manotas | Tijuana |
| 4 | Ian Torres | Atlas |
| 4 | Michael Rangel | Mazatlan |
| 4 | Erick Sanchez | Pachuca |
| 4 | Daniel Alvarez | Puebla |
| 4 | Juan Dinenno | Pumas |
| 4 | Carlos Gonzalez | Tigres |
| 3 | Emmanuel Aguilera | America |
| 3 | Pedro Aquino | America |
| 3 | Richard Sanchez | America |
| 3 | Aldo Rocha | Atlas |
| 3 | Jonathan Herrera | Atlas |
| 3 | Brayan Angulo | Cruz Azul |
| 3 | Guillermo Fernandez | Cruz Azul |
| 3 | Luis Romo | Cruz Azul |
| 3 | Roberto Alvarado | Cruz Azul |
| 3 | Jesus Angulo | Guadalajara |
| 3 | Jesus Molina | Guadalajara |
| 3 | Francisco Aristeguieta | Mazatlan |
| 3 | Giovanni Augusto | Mazatlan |
| 3 | Ian Gonzalez | Necaxa |
| 3 | Martin Barragan | Necaxa |
| 3 | Ismael Sosa | Pachuca |
| 3 | Christian Alejandro Tabo | Puebla |
| 3 | Hugo Silveira | Queretaro |
| 3 | German Berterame | San Luis |
| 3 | Diego Valdes | Santos |
| 3 | Eduar Preciado | Santos |
| 3 | Fernando Gorriaran | Santos |
| 3 | Juan Ferney Otero | Santos |
| 3 | Santiago Muñoz | Santos |
| 3 | Andre-Pierre Gignac | Tigres |
| 3 | Diego Reyes | Tigres |
| 3 | Kevin Castañeda | Toluca |
| 2 | Francisco Cordova | America |
| 2 | Leandro Suarez | America |
| 2 | Alex Renato Ibarra | Atlas |
| 2 | Julio Furch | Atlas |
| 2 | Elias Hernandez | Cruz Azul |
| 2 | Juan Escobar | Cruz Azul |
| 2 | Orbelin Pineda | Cruz Azul |
| 2 | Santiago Gimenez | Cruz Azul |
| 2 | Carlos Uriel Antuna | Guadalajara |
| 2 | Ernesto Vega | Guadalajara |
| 2 | Manuel Mayorga | Guadalajara |
| 2 | Miguel Ponce | Guadalajara |
| 2 | Ariel Matias Garcia | Juarez |
| 2 | Victor Velazquez | Juarez |
| 2 | Emmanuel Gigliotti | Leon |
| 2 | Jean Meneses | Leon |
| 2 | Nicolas Diaz | Mazatlan |
| 2 | Arturo Gonzalez | Monterrey |
| 2 | Alejandro Zendejas | Necaxa |
| 2 | Juan Delgado | Necaxa |
| 2 | Maximiliano Salas | Necaxa |
| 2 | Erick Aguirre | Pachuca |
| 2 | Gustavo Cabral | Pachuca |
| 2 | Luis Chavez | Pachuca |
| 2 | Mauro Quiroga | Pachuca |
| 2 | Oscar Murillo | Pachuca |
| 2 | Romario Ibarra | Pachuca |
| 2 | Maximiliano Araujo | Puebla |
| 2 | Salvador Reyes | Puebla |
| 2 | Kevin Ramirez | Queretaro |
| 2 | Juan Castro | San Luis |
| 2 | Luis Felipe Gallegos | San Luis |
| 2 | Ramiro Gonzalez | San Luis |
| 2 | Doria | Santos |
| 2 | Edgar Lopez | Tijuana |
| 2 | Fabian Castillo | Tijuana |
| 2 | Miguel Barbieri | Toluca |
| 1 | Federico Viñas | America |
| 1 | Giovanni dos Santos | America |
| 1 | Luis Fuentes | America |
| 1 | Mauro Lainez | America |
| 1 | Santiago Naveda | America |
| 1 | Anderson Santamaria | Atlas |
| 1 | Angel Marquez | Atlas |
| 1 | Edgar Zaldivar | Atlas |
| 1 | Milton Caraglio | Atlas |
| 1 | Victor Malcorra | Atlas |
| 1 | Adrian Aldrete | Cruz Azul |
| 1 | Pablo Aguilar | Cruz Azul |
| 1 | Angel Zaldivar | Guadalajara |
| 1 | Isaac Brizuela | Guadalajara |
| 1 | Jesus Sanchez | Guadalajara |
| 1 | Francisco Contreras | Juarez |
| 1 | Luis Pavez | Juarez |
| 1 | Martin Galvan | Juarez |
| 1 | William Mendieta | Juarez |
| 1 | Fernando Navarro | Leon |
| 1 | Fidel Ambriz | Leon |
| 1 | Jaime Barreiro | Leon |
| 1 | Joel Campbell | Leon |
| 1 | Luis Montes | Leon |
| 1 | Osvaldo Rodriguez | Leon |
| 1 | Santiago Colombo | Leon |
| 1 | Carlos Vargas | Mazatlan |
| 1 | Ake Loba | Monterrey |
| 1 | Jose Alvarado | Monterrey |
| 1 | Sebastian Vegas | Monterrey |
| 1 | Daniel Lopez | Necaxa |
| 1 | Felipe Pardo | Pachuca |
| 1 | Kevin Alvarez | Pachuca |
| 1 | Roberto Nurse | Pachuca |
| 1 | Daniel Aguilar | Puebla |
| 1 | Emanuel Gularte | Puebla |
| 1 | Guillermo Martinez | Puebla |
| 1 | Juan Pablo Segovia | Puebla |
| 1 | Maximiliano Perg | Puebla |
| 1 | Carlos Gutierrez | Pumas |
| 1 | Emanuel Montejano | Pumas |
| 1 | Facundo Waller | Pumas |
| 1 | Gabriel Torres | Pumas |
| 1 | Juan Pablo Vigon | Pumas |
| 1 | Sebastian Saucedo | Pumas |
| 1 | Chico | Queretaro |
| 1 | Fernando Madrigal | Queretaro |
| 1 | Gonzalo Montes | Queretaro |
| 1 | Joe Gallardo | Queretaro |
| 1 | Jose Doldan | Queretaro |
| 1 | Juan Gurrola | Queretaro |
| 1 | Luis Antonio Valencia | Queretaro |
| 1 | Felix Torres | Santos |
| 1 | Jesus Ocejo | Santos |
| 1 | Omar Campos | Santos |
| 1 | Ronaldo Prieto | Santos |
| 1 | Carlos Salcedo | Tigres |
| 1 | Julian Quiñones | Tigres |
| 1 | Luis Quiñones | Tigres |
| 1 | David Barbona | Tijuana |
| 1 | Miguel Sansores | Tijuana |
| 1 | Diego | Toluca |
| 1 | Joao Plata | Toluca |
| 1 | Jorge Torres | Toluca |
| 1 | Raul Lopez | Toluca |
| 1 | Ruben Sambueza | Toluca |
| Autogoles | ||
| Jugador | Equipo | |
| 1 | Anderson Santamaria | Atlas |
| 1 | Julio Dominguez | Cruz Azul |
| 1 | Antonio Briseño | Guadalajara |
| 1 | Jose Macias | Guadalajara |
| 1 | Pol Garcia | Juarez |
| 1 | Andres Mosquera | Leon |
| 1 | Jose Ortiz | Mazatlan |
| 1 | Hugo Magallanes | Queretaro |
| 1 | Victor Guzman | Tijuana |