| GOLEADORES CAMPEONATO APERTURA 2021 | ||
| Goles | Jugador | Equipo |
| 10 | Angel Mena | Leon |
| 9 | Julio Furch | Atlas |
| 9 | German Berterame | San Luis |
| 9 | Nicolas Lopez | Tigres |
| 8 | Camilo Sanvezzo | Mazatlan |
| 7 | Victor Davila | Leon |
| 7 | Juan Dinenno | Pumas |
| 6 | Rogerio Funes Mori | Monterrey |
| 6 | Alejandro Zendejas | Necaxa |
| 6 | Christian Alejandro Tabo | Puebla |
| 6 | Diego Valdes | Santos |
| 5 | Julian Quiñones | Atlas |
| 5 | Washington Corozo | Pumas |
| 4 | Alvaro Fidalgo | America |
| 4 | Brayan Angulo | Cruz Azul |
| 4 | Roberto Alvarado | Cruz Azul |
| 4 | Santiago Gimenez | Cruz Azul |
| 4 | Angel Zaldivar | Guadalajara |
| 4 | Elias Hernandez | Leon |
| 4 | Arturo Gonzalez | Monterrey |
| 4 | Duvan Vergara | Monterrey |
| 4 | Maximiliano Meza | Monterrey |
| 4 | Jonathan dos Santos | Queretaro |
| 4 | Fernando Gorriaran | Santos |
| 4 | Andre-Pierre Gignac | Tigres |
| 4 | Carlos Gonzalez | Tigres |
| 4 | Juan Pablo Vigon | Tigres |
| 4 | Mauro Manotas | Tijuana |
| 4 | Alexis Canelo | Toluca |
| 4 | Oscar Ortega | Toluca |
| 4 | Rubens Sambueza | Toluca |
| 3 | Francisco Cordova | America |
| 3 | Roger Martinez | America |
| 3 | Salvador Reyes | America |
| 3 | Jonathan Rodriguez | Cruz Azul |
| 3 | Isaac Brizuela | Guadalajara |
| 3 | Gabriel Fernandez | Juarez |
| 3 | Luis Garcia | Necaxa |
| 3 | Victor Guzman | Pachuca |
| 3 | Guillermo Martinez | Puebla |
| 3 | Alessio da Cruz | Santos |
| 3 | Eduar Ayrton Preciado | Santos |
| 3 | Luis Quiñones | Tigres |
| 3 | Lucas Rodriguez | Tijuana |
| 3 | Ian Gonzalez | Toluca |
| 2 | Emmanuel Aguilera | America |
| 2 | Henry Martin | America |
| 2 | Aldo Rocha | Atlas |
| 2 | Christopher Trejo | Atlas |
| 2 | Diego Barbosa | Atlas |
| 2 | Hugo Nervo | Atlas |
| 2 | Luis Reyes | Atlas |
| 2 | Lucas Passerini | Cruz Azul |
| 2 | Victor Yotun | Cruz Azul |
| 2 | Manuel Mayorga | Guadalajara |
| 2 | Diego Rolan | Juarez |
| 2 | Jefferson Intriago | Juarez |
| 2 | Martin Galvan | Juarez |
| 2 | Pedro Raul | Juarez |
| 2 | William Tesillo | Leon |
| 2 | Bryan Colula | Mazatlan |
| 2 | Maximiliano Salas | Necaxa |
| 2 | Rodrigo Aguirre | Necaxa |
| 2 | Gustavo Cabral | Pachuca |
| 2 | Luis Chavez | Pachuca |
| 2 | Nicolas Ibañez | Pachuca |
| 2 | Roberto de la Rosa | Pachuca |
| 2 | Yairo Moreno | Pachuca |
| 2 | Pablo Parra | Puebla |
| 2 | Arturo Ortiz | Pumas |
| 2 | Diogo | Pumas |
| 2 | Fabio Alvarez | Pumas |
| 2 | Adam Bareiro | San Luis |
| 2 | Andres Vombergar | San Luis |
| 2 | Brian Lozano | Santos |
| 2 | Eduardo Aguirre | Santos |
| 2 | Felix Torres | Santos |
| 2 | Carlos Salcedo | Tigres |
| 2 | Florian Thauvin | Tigres |
| 2 | Brayan Angulo | Tijuana |
| 2 | Vladimir Loroña | Tijuana |
| 2 | Braian Samudio | Toluca |
| 2 | Diego Chavez | Toluca |
| 2 | Raul Lopez | Toluca |
| 1 | Alex Renato Ibarra | America |
| 1 | Federico Viñas | America |
| 1 | Fernando Madrigal | America |
| 1 | Mauro Lainez | America |
| 1 | Richard Sanchez | America |
| 1 | Anderson Santamaria | Atlas |
| 1 | Ian Torres | Atlas |
| 1 | Luis Romo | Cruz Azul |
| 1 | Orbelin Pineda | Cruz Azul |
| 1 | Cesar Huerta | Guadalajara |
| 1 | Gilberto Sepulveda | Guadalajara |
| 1 | Jesus Ricardo Angulo | Guadalajara |
| 1 | Jose Godinez | Guadalajara |
| 1 | Ronaldo Cisneros | Guadalajara |
| 1 | Maximiliano Olivera | Juarez |
| 1 | Pol Garcia | Juarez |
| 1 | Victor Velazquez | Juarez |
| 1 | Emmanuel Gigliotti | Leon |
| 1 | Jaime Barreiro | Leon |
| 1 | Jean Meneses | Leon |
| 1 | Santiago Colombatto | Leon |
| 1 | Daniel Amador | Mazatlan |
| 1 | Emilio Sanchez | Mazatlan |
| 1 | Giovanni Augusto | Mazatlan |
| 1 | Ivan Moreno | Mazatlan |
| 1 | Nestor Vidrio | Mazatlan |
| 1 | Nicolas Diaz | Mazatlan |
| 1 | Carlos Rodriguez | Monterrey |
| 1 | Erick Aguirre | Monterrey |
| 1 | Jesus Gallardo | Monterrey |
| 1 | Jose Alvarado | Monterrey |
| 1 | Matias Kranevitter | Monterrey |
| 1 | Vincent Janssen | Monterrey |
| 1 | Alan Medina | Necaxa |
| 1 | Jesus Escoboza | Necaxa |
| 1 | Aviles Hurtado | Pachuca |
| 1 | Bryan Gonzalez | Pachuca |
| 1 | Erick Sanchez | Pachuca |
| 1 | Kevin Alvarez | Pachuca |
| 1 | Matias Catalan | Pachuca |
| 1 | Amaury Escoto | Puebla |
| 1 | Daniel Alvarez | Puebla |
| 1 | Diego de Buen | Puebla |
| 1 | Dieter Villalpando | Puebla |
| 1 | Emanuel Gularte | Puebla |
| 1 | Francisco Aristeguieta | Puebla |
| 1 | George Corral | Puebla |
| 1 | Lucas Maia | Puebla |
| 1 | Maximiliano Araujo | Puebla |
| 1 | Rogerio | Puebla |
| 1 | Higor | Pumas |
| 1 | Leonel Lopez | Pumas |
| 1 | Marco Garcia | Pumas |
| 1 | Sebastian Saucedo | Pumas |
| 1 | Bryan Olivera | Queretaro |
| 1 | Erick Vera | Queretaro |
| 1 | Kevin Escamilla | Queretaro |
| 1 | Kevin Ramirez | Queretaro |
| 1 | Nicolas Sosa | Queretaro |
| 1 | Pablo Barrera | Queretaro |
| 1 | Facundo Waller | San Luis |
| 1 | Jesus Piñuelas | San Luis |
| 1 | Jhon Duque | San Luis |
| 1 | Jose Lozano | San Luis |
| 1 | Unai Bilbao | San Luis |
| 1 | Doria | Santos |
| 1 | Ignacio Jeraldino | Santos |
| 1 | Jesus Ocejo | Santos |
| 1 | Juan Ferney Otero | Santos |
| 1 | Omar Campos | Santos |
| 1 | Diego Reyes | Tigres |
| 1 | Guido Pizarro | Tigres |
| 1 | Raymundo Fulgencio | Tigres |
| 1 | Erick Castillo | Tijuana |
| 1 | Fidel Martinez | Tijuana |
| 1 | Miguel Sansores | Tijuana |
| 1 | Diego | Toluca |
| 1 | Oscar Vanegas | Toluca |
| Autogoles | ||
| Jugador | Equipo | |
| 1 | Jose Ignacio Rivero | Cruz Azul |
| 1 | Jose Garcia | Juarez |
| 1 | Esteban Andrada | Monterrey |
| 1 | Fabricio Formiliano | Necaxa |
| 1 | Julio Gonzalez | Necaxa |
| 1 | Oscar Murillo | Pachuca |
| 1 | Yairo Moreno | Pachuca |
| 1 | Juan Pablo Segovia | Puebla |
| 1 | Unai Bilbao | San Luis |
| 1 | Guido Pizarro | Tigres |
| 1 | Hugo Ayala | Tigres |