| GOLEADORES MLS 2021 | ||
| Goles | Jugador | Equipo |
| 22 | Valentin Castellanos | New York City |
| 19 | Ola Kamara | DC United |
| 19 | Hany Mukhtar | Nashville |
| 17 | Javier Hernandez | Galaxy |
| 17 | Adam Buksa | New England |
| 17 | Raul Ruidiaz | Seattle |
| 16 | Daniel Salloi | Kansas City |
| 16 | Johnny Russell | Kansas City |
| 16 | Damir Kreilach | Real Salt Lake |
| 15 | Gustavo Bou | New England |
| 14 | Cristian Arango | Los Angeles |
| 13 | Ricardo Pepi | Dallas |
| 13 | Felipe Mora | Portland |
| 12 | Josef Martinez | Atlanta |
| 12 | Lucas Zelarayan | Columbus |
| 12 | Gonzalo Higuain | Miami |
| 12 | Charles Sapong | Nashville |
| 12 | Kacper Przybylko | Philadelphia |
| 12 | Javier Lopez | San Jose |
| 12 | Brian White | Vancouver |
| 11 | Fabrice Picault | Houston |
| 11 | Daryl Dike | Orlando |
| 11 | Albert Rusnak | Real Salt Lake |
| 11 | Cristian Dajome | Vancouver |
| 10 | Nani | Orlando |
| 10 | Dairon Asprilla | Portland |
| 9 | Damian Marcelino Moreno | Atlanta |
| 9 | Gyasi Zardes | Columbus |
| 9 | Jader Obrian | Dallas |
| 9 | Robin Lod | Minnesota |
| 9 | Tajon Buchanan | New England |
| 9 | Jesus Medina | New York City |
| 9 | Sebastian Blanco | Portland |
| 9 | Anderson Julio | Real Salt Lake |
| 8 | Luka Stojanović | Chicago |
| 8 | Robert Berič | Chicago |
| 8 | Brenner | Cincinnati |
| 8 | Michael Barrios | Colorado |
| 8 | Miguel Berry | Columbus |
| 8 | Jesus Ferreira | Dallas |
| 8 | Alan Pulido | Kansas City |
| 8 | Rommel Quioto | Montreal |
| 8 | Randal Leal | Nashville |
| 8 | Rubio Mendez | Real Salt Lake |
| 8 | Patryk Klimala | Red Bulls |
| 7 | Ezequiel Barco | Atlanta |
| 7 | Cecilio Dominguez | Austin |
| 7 | Diego Fagundez | Austin |
| 7 | Luciano Acosta | Cincinnati |
| 7 | Jonathan Lewis | Colorado |
| 7 | Franco Jara | Dallas |
| 7 | Maximiliano Urruti | Houston |
| 7 | Adrien Hunou | Minnesota |
| 7 | Mason Toye | Montreal |
| 7 | Ismael Tajouri | New York City |
| 7 | Fabio | Red Bulls |
| 7 | Fredy Montero | Seattle |
| 6 | Paul Arriola | DC United |
| 6 | Diego Rossi | Los Angeles |
| 6 | Franco Fragapane | Minnesota |
| 6 | Sergio Santos | Philadelphia |
| 6 | Yimmi Chara | Portland |
| 6 | Cristian Casseres | Red Bulls |
| 6 | Cristian Roldan | Seattle |
| 5 | Sebastian Driussi | Austin |
| 5 | Cole Bassett | Colorado |
| 5 | Diego Rubio | Colorado |
| 5 | Dominique Badji | Colorado |
| 5 | Ramon Abila | DC United-Minnesota |
| 5 | Kevin Cabral | Galaxy |
| 5 | Sacha Klještan | Galaxy |
| 5 | Gadi Kinda | Kansas City |
| 5 | Carlos Vela | Los Angeles |
| 5 | Jose Cifuentes | Los Angeles |
| 5 | Emanuel Reynoso | Minnesota |
| 5 | Daniel Gazdag | Philadelphia |
| 5 | Jeremy Ebobisse | Portland-San Jose |
| 5 | Cade Cowell | San Jose |
| 5 | Chris Wondolowski | San Jose |
| 5 | Deiber Caicedo | Vancouver |
| 4 | Luiz Araujo | Atlanta |
| 4 | Alexander Ring | Austin |
| 4 | Ignacio Aliseda | Chicago |
| 4 | Brandon Vazquez | Cincinnati |
| 4 | Andre Shinyanshiki | Colorado |
| 4 | Pedro Santos | Columbus |
| 4 | Jose Yordy Reyna | DC United |
| 4 | Nigel Robertha | DC United |
| 4 | Rayan Raveloson | Galaxy |
| 4 | Tyler Pasher | Houston |
| 4 | Khiry Shelton | Kansas City |
| 4 | Brian Rodriguez | Los Angeles |
| 4 | Daniel Musovski | Los Angeles |
| 4 | Mamadou Fall | Los Angeles |
| 4 | Robbie Robinson | Miami |
| 4 | Djordje Mihailovic | Montreal |
| 4 | Ibrahim Sunusi | Montreal |
| 4 | Joaquin Torres | Montreal |
| 4 | Teal Bunbury | New England |
| 4 | Keaton Parks | New York City |
| 4 | Maximiliano Moralez | New York City |
| 4 | Santiago Rodriguez | New York City |
| 4 | Thiago | New York City |
| 4 | Benji Michel | Orlando |
| 4 | Junior Urso | Orlando |
| 4 | Cory Burke | Philadelphia |
| 4 | Jakob Glesnes | Philadelphia |
| 4 | Cadenadi Clark | Red Bulls |
| 4 | Benjamin Kikanovic | San Jose |
| 4 | Jimmy Medranda | Seattle |
| 4 | Jonathan Osorio | Toronto |
| 4 | Jozy Altidore | Toronto |
| 4 | Ryan Gauld | Vancouver |
| 3 | Jon Gallagher | Austin |
| 3 | Alvaro Medran | Chicago |
| 3 | Alvaro Barreal | Cincinnati |
| 3 | Haris Medunjanin | Cincinnati |
| 3 | Kevin Paredes | DC United |
| 3 | Samuel Grandsir | Galaxy |
| 3 | Sebastian Lletget | Galaxy |
| 3 | Victor Vazquez | Galaxy |
| 3 | Carlos Darwin Quintero | Houston |
| 3 | Matias Vera | Houston |
| 3 | Corey Baird | Los Angeles |
| 3 | Federico Higuain | Miami |
| 3 | Indiana Vassilev | Miami |
| 3 | Rodolfo Pizarro | Miami |
| 3 | Ethan Finlay | Minnesota |
| 3 | Rudy Camacho | Montreal |
| 3 | Alexander Muyl | Nashville |
| 3 | Jhonder Cadiz | Nashville |
| 3 | Walker Zimmerman | Nashville |
| 3 | Carles Gil | New England |
| 3 | Dejuan Jones | New England |
| 3 | Talles Magno | New York City |
| 3 | Christopher Mueller | Orlando |
| 3 | Robert Jansson | Orlando |
| 3 | Silvester van der Water | Orlando |
| 3 | Tesho Akindele | Orlando |
| 3 | Alejandro Bedoya | Philadelphia |
| 3 | Kai Wagner | Philadelphia |
| 3 | Paxten Aaronson | Philadelphia |
| 3 | Cristhian Paredes | Portland |
| 3 | Jaroslaw Niezgoda | Portland |
| 3 | Bobby Wood | Real Salt Lake |
| 3 | Omir Fernandez | Red Bulls |
| 3 | Carlos Fierro | San Jose |
| 3 | Cristian Espinoza | San Jose |
| 3 | Jackson Yueill | San Jose |
| 3 | Bradley Smith | Seattle |
| 3 | João Paulo | Seattle |
| 3 | Nicolas Benezet | Seattle |
| 3 | Will Bruin | Seattle |
| 3 | Ayomide Akinola | Toronto |
| 3 | Jacob Shaffelburg | Toronto |
| 3 | Marco Delgado | Toronto |
| 3 | Omar Gonzalez | Toronto |
| 3 | Richie Laryea | Toronto |
| 3 | Lucas Cavallini | Vancouver |
| 2 | Anton Walkes | Atlanta |
| 2 | Julio Cascante | Austin |
| 2 | Tomas Pochettino | Austin |
| 2 | Boris Sekulić | Chicago |
| 2 | Gaston Gimenez | Chicago |
| 2 | Przemyslaw Frankowski | Chicago |
| 2 | Exson Gustavo Vallecilla | Cincinnati |
| 2 | Ronald Matarrita | Cincinnati |
| 2 | Alhassan Abubakar | Colorado |
| 2 | Brian Galvan | Colorado |
| 2 | Daniel Wilson | Colorado |
| 2 | Keegan Rosenberry | Colorado |
| 2 | Darlington Nagbe | Columbus |
| 2 | Jonathan Mensah | Columbus |
| 2 | Ryan Hollingshead | Dallas |
| 2 | Edison Flores | DC United |
| 2 | Julian Gressel | DC United |
| 2 | Steven Birnbaum | DC United |
| 2 | Yamil Asad | DC United |
| 2 | Dejan Joveljić | Galaxy |
| 2 | Efrain Alvarez | Galaxy |
| 2 | Griffin Dorsey | Houston |
| 2 | Jose Rodriguez | Houston |
| 2 | Cameron Duke | Kansas City |
| 2 | Gianluca Busio | Kansas City |
| 2 | Javlin Lindsey | Kansas City |
| 2 | Eduard Atuesta | Los Angeles |
| 2 | Latif Blessing | Los Angeles |
| 2 | Brek Shea | Miami |
| 2 | Christian Makoun | Miami |
| 2 | Lewis Morgan | Miami |
| 2 | Brent Kallman | Minnesota |
| 2 | Hassani Dotson | Minnesota |
| 2 | Ahmed Hamdi | Montreal |
| 2 | Bjorn Johnsen | Montreal |
| 2 | Mathieu Choiniere | Montreal |
| 2 | Victor Wanyama | Montreal |
| 2 | Zachary Brault-Guillard | Montreal |
| 2 | Luke Haakenson | Nashville |
| 2 | Arnor Traustason | New England |
| 2 | Brandon Bye | New England |
| 2 | Emmanuel Boateng | New England |
| 2 | Matt Polster | New England |
| 2 | Thomas McNamara | New England |
| 2 | Alexander Callens | New York City |
| 2 | Gudhmundur Thorarinsson | New York City |
| 2 | Andres Perea | Orlando |
| 2 | Antonio Carlos | Orlando |
| 2 | Ruan | Orlando |
| 2 | Jack Elliott | Philadelphia |
| 2 | Jamiro Monteiro | Philadelphia |
| 2 | Quinn Sullivan | Philadelphia |
| 2 | Diego Chara | Portland |
| 2 | Diego Valeri | Portland |
| 2 | George Fochive | Portland |
| 2 | Larrys Mabiala | Portland |
| 2 | Marvin Loria | Portland |
| 2 | Justen Glad | Real Salt Lake |
| 2 | Justin Meram | Real Salt Lake |
| 2 | Maikel Chang | Real Salt Lake |
| 2 | Andres Reyes | Red Bulls |
| 2 | Andrew Gutman | Red Bulls |
| 2 | Nathan | San Jose |
| 2 | Oswaldo Alanis | San Jose |
| 2 | Xavier Arreaga | Seattle |
| 2 | Ifunanyachi Achara | Toronto |
| 2 | Yeferson Soteldo | Toronto |
| 2 | Andy Rose | Vancouver |
| 2 | Erik Godoy | Vancouver |
| 1 | Emerson Hyndman | Atlanta |
| 1 | Erik Lopez | Atlanta |
| 1 | George Bello | Atlanta |
| 1 | George Campbell | Atlanta |
| 1 | Jackson Conway | Atlanta |
| 1 | Jake Mulraney | Atlanta |
| 1 | Miles Robinson | Atlanta |
| 1 | Ronald Hernandez | Atlanta |
| 1 | Hector Jimenez | Austin |
| 1 | Jared Stroud | Austin |
| 1 | McKinze Gaines II | Austin |
| 1 | Moussa Djitte | Austin |
| 1 | Carlos Teran | Chicago |
| 1 | Chinonso Nnamdi | Chicago |
| 1 | Federico Navarro | Chicago |
| 1 | Francisco Calvo | Chicago |
| 1 | Mauricio Pineda | Chicago |
| 1 | Allan Cruz | Cincinnati |
| 1 | Edgar Castillo | Cincinnati |
| 1 | Isaac Atanga | Cincinnati |
| 1 | Jurgen Locadia | Cincinnati |
| 1 | Nick Hagglund | Cincinnati |
| 1 | Tyler Blackett | Cincinnati |
| 1 | Zico Bailey | Cincinnati |
| 1 | Auston Trusty | Colorado |
| 1 | Collen Warner | Colorado |
| 1 | Gabriel Nicolas Mezquida | Colorado |
| 1 | Kellyn Acosta | Colorado |
| 1 | Lucas Esteves | Colorado |
| 1 | Mark Kaye | Colorado |
| 1 | Samuel Vines | Colorado |
| 1 | Younes Namli | Colorado |
| 1 | Bradley Wright-Phillips | Columbus |
| 1 | Derick Etienne | Columbus |
| 1 | Kevin Molino | Columbus |
| 1 | Luis Diaz | Columbus |
| 1 | Andres Ricaurte | Dallas |
| 1 | Bressan | Dallas |
| 1 | Dante Sealy | Dallas |
| 1 | Matt Hedges | Dallas |
| 1 | Nkosi Burgess | Dallas |
| 1 | Paxton Pomykal | Dallas |
| 1 | Andy Najar | DC United |
| 1 | Brendan Hines-Ike | DC United |
| 1 | Felipe Martins | DC United |
| 1 | Frederic Brillant | DC United |
| 1 | Griffins Yow | DC United |
| 1 | Jose Antonio Alfaro | DC United |
| 1 | Junior Moreno | DC United |
| 1 | Russell Canouse | DC United |
| 1 | Jonathan dos Santos | Galaxy |
| 1 | Adalberto Carrasquilla | Houston |
| 1 | Christian Ramirez | Houston |
| 1 | Felipe Hernandez | Kansas City |
| 1 | Graham Zusi | Kansas City |
| 1 | Ilie Sanchez Farres | Kansas City |
| 1 | Jose Mauri | Kansas City |
| 1 | Luis Martins | Kansas City |
| 1 | Nicolas Isimat-Mirin | Kansas City |
| 1 | Remi Walter | Kansas City |
| 1 | Ethan Zubak | Los Angeles |
| 1 | Kim Moon Hwan | Los Angeles |
| 1 | Tristan Blackmon | Los Angeles |
| 1 | Blaise Matuidi | Miami |
| 1 | Jorge Figal | Miami |
| 1 | Julian Carranza | Miami |
| 1 | Kieran Gibbs | Miami |
| 1 | Bakaye Dibassy | Minnesota |
| 1 | Chase Gasper | Minnesota |
| 1 | Fanendo Adi | Minnesota |
| 1 | Niko Hansen | Minnesota |
| 1 | Osvaldo Alonso | Minnesota |
| 1 | Will Trapp | Minnesota |
| 1 | Aljaz Struna | Montreal |
| 1 | Kamal Miller | Montreal |
| 1 | Lassi Lappalainen | Montreal |
| 1 | Matko Miljevic | Montreal |
| 1 | Samuel Piette | Montreal |
| 1 | Abu Danladi | Nashville |
| 1 | Ake Loba | Nashville |
| 1 | Alistair Johnston | Nashville |
| 1 | Brian Anunga | Nashville |
| 1 | Daniel Rios | Nashville |
| 1 | Jack Maher | Nashville |
| 1 | Jalil Anibaba | Nashville |
| 1 | Robert Castellanos | Nashville |
| 1 | Henry Kessler | New England |
| 1 | Jonathan Bell | New England |
| 1 | Wilfrid Kaptoum | New England |
| 1 | Malte Amundsen | New York City |
| 1 | Jhegson Mendez | Orlando |
| 1 | Kyle Smith | Orlando |
| 1 | Mauricio Pereyra | Orlando |
| 1 | Leon Flach | Philadelphia |
| 1 | Bill Tuiloma | Portland |
| 1 | Eryk Williamson | Portland |
| 1 | Santiago Moreno | Portland |
| 1 | Aaron Herrera | Real Salt Lake |
| 1 | Erik Holt | Real Salt Lake |
| 1 | Jonathan Menendez | Real Salt Lake |
| 1 | Dru Yearwood | Red Bulls |
| 1 | Franuel Amaya | Red Bulls |
| 1 | John Tolkin | Red Bulls |
| 1 | Kyle Duncan | Red Bulls |
| 1 | Sean Nealis | Red Bulls |
| 1 | Tom Barlow | Red Bulls |
| 1 | Wikelman Carmona | Red Bulls |
| 1 | Marcos Lopez | San Jose |
| 1 | Paul Marie | San Jose |
| 1 | Alexander Roldan | Seattle |
| 1 | Kelyn Rowe | Seattle |
| 1 | Leo Chu | Seattle |
| 1 | Shane O'Neill | Seattle |
| 1 | Yeimar Gomez | Seattle |
| 1 | Alejandro Pozuelo | Toronto |
| 1 | Jordan Perruzza | Toronto |
| 1 | Luke Singh | Toronto |
| 1 | Michael Bradley | Toronto |
| 1 | Nicholas DeLeon | Toronto |
| 1 | Patrick Mullins | Toronto |
| 1 | Ralph Priso-Mbongue | Toronto |
| 1 | Bruno Gaspar | Vancouver |
| 1 | Florian Jungwirth | Vancouver |
| 1 | Jakob Nerwinski | Vancouver |
| 1 | Janio Bikel | Vancouver |
| 1 | Ranko Veselinović | Vancouver |
| 1 | Russell Teibert | Vancouver |
| Autogoles | ||
| Jugador | Equipo | |
| 2 | Zarek Valentin | Houston |
| 2 | Ranko Veselinović | Vancouver |
| 1 | Julio Cascante | Austin |
| 1 | Boris Sekulić | Chicago |
| 1 | Carlos Teran | Chicago |
| 1 | Johan Kappelhof | Chicago |
| 1 | Nick Hagglund | Cincinnati |
| 1 | William Yarbrough | Colorado |
| 1 | Tanner Tessmann | Dallas |
| 1 | Andy Najar | DC United |
| 1 | Brendan Hines-Ike | DC United |
| 1 | Frederic Brillant | DC United |
| 1 | Jose Alfaro | DC United |
| 1 | Steven Birnbaum | DC United |
| 1 | Julian Araujo | Galaxy |
| 1 | Marko Maric | Galaxy |
| 1 | Nicholas Hamalainen | Galaxy |
| 1 | Kieran Gibbs | Miami |
| 1 | leandro Gonzalez Pirez | Miami |
| 1 | Bakaye Dibassy | Minnesota |
| 1 | Michael Boxall | Minnesota |
| 1 | James Pantenis | Montreal |
| 1 | Rudy Camacho | Montreal |
| 1 | Brian Anunga | Nashville |
| 1 | David Romney | Nashville |
| 1 | Andrew Farrell | New England |
| 1 | Alexander Callens | New York City |
| 1 | Vuk Latinovich | New York City |
| 1 | Antonio Carlos | Orlando |
| 1 | Daryl Dike | Orlando |
| 1 | Rodrigo Schlegel | Orlando |
| 1 | Jack Elliott | Philadelphia |
| 1 | Jakob Glesnes | Philadelphia |
| 1 | Kacper Przybylko | Philadelphia |
| 1 | Cristhian Paredes | Portland |
| 1 | Aaron Herrera | Real Salt Lake |
| 1 | Marcelo Silva | Real Salt Lake |
| 1 | Toni Datković | Real Salt Lake |
| 1 | Florian Jungwirth | San Jose |
| 1 | Jackson Yueill | San Jose |
| 1 | Tanner Beason | San Jose |
| 1 | Shane O'Neill | Seattle |
| 1 | Eriq Zavaleta | Toronto |
| 1 | Ralph Priso-Mbongue | Toronto |