| 1ª Semana | ||||||
| 25/03/2010 | Seattle | Sounders | 2 | Evans, Montero | ||
| Union | 0 | |||||
| 26/03/2010 | Carson | Chivas USA | 0 | |||
| Rapids | 1 | Cummings | ||||
| 27/03/2010 | Columbus | Crew | 2 | Iro, Barros Schelotto | ||
| Toronto | 0 | |||||
| 27/03/2010 | Frisco | Dallas | 1 | Harris | ||
| Dynamo | 1 | Chabala | ||||
| 27/03/2010 | New York | Red Bulls | 1 | Lindpere | ||
| Fire | 0 | |||||
| 27/03/2010 | Kansas City | Wizards | 4 | Kamara, Arnaud, Smith, Jewsbury (P) | ||
| DC United | 0 | |||||
| 27/03/2010 | Santa Clara | Earthquakes | 0 | |||
| Real Salta Lake | 3 | Morales (2), Espindola | ||||
| 27/03/2010 | Carson | Galaxy | 1 | Buddle | ||
| Revolution | 0 | |||||
| 2ª Semana | ||||||
| 01/04/2010 | Houston | Dynamo | 2 | Davis (2P) | ||
| Real Salt Lake | 1 | Morales | ||||
| 01/04/2010 | Carson | Galaxy | 2 | Buddle (2) | ||
| Chivas USA | 0 | |||||
| 03/04/2010 | Commerce City | Rapids | 2 | Cummings, Casey (P) | ||
| Fire | 2 | John, McBride (P) | ||||
| 03/04/2010 | Washington | DC United | 0 | |||
| Revolution | 2 | Mansally (2) | ||||
| 03/04/2010 | Seattle | Sounders | 0 | |||
| Red Bulls | 1 | Kandji | ||||
| 3ª Semana | ||||||
| 10/04/2010 | Carson | Chivas USA | 2 | Coundoul (A), Padilla | ||
| Red Bulls | 0 | |||||
| 10/04/2010 | Philadelphia | Union | 3 | Le Toux (3) | ||
| DC United | 2 | Quaranta, Moreno | ||||
| 10/04/2010 | Foxborough | Revolution | 4 | Schilawski (3), Nyassi | ||
| Toronto | 1 | De Rosario | ||||
| 10/04/2010 | Bridgeview | Fire | 1 | Pappa | ||
| Earthquakes | 2 | Alvarez, Opara | ||||
| 10/04/2010 | Frisco | Dallas | 2 | Cunningham (P), Avila | ||
| Crew | 2 | Moffat, Barros Schelotto | ||||
| 10/04/2010 | Houston | Dynamo | 0 | |||
| Galaxy | 2 | Buddle (2) | ||||
| 10/04/2010 | Kansas City | Wizards | 1 | Kamara | ||
| Rapids | 0 | |||||
| 10/04/2010 | Sandy | Real Salt Lake | 2 | Johnson, Saborio | ||
| Sounders | 2 | Zakuani, Noonan | ||||
| 4ª Semana | ||||||
| 15/04/2010 | Toronto | Toronto | 2 | De Rosario (2, 1P) | ||
| Union | 1 | Harvey | ||||
| 17/04/2010 | Seattle | Sounders | 1 | Fucito | ||
| Wizards | 0 | |||||
| 17/04/2010 | Houston | Dynamo | 3 | Cameron, Palmer, Oduro | ||
| Chivas USA | 0 | |||||
| 17/04/2010 | Washington | DC United | 0 | |||
| Fire | 2 | Pappa, McBride | ||||
| 17/04/2010 | New York | Red Bulls | 2 | Angel (2, 1P) | ||
| Dallas | 1 | McCarty | ||||
| 17/04/2010 | Santa Clara | Earthquakes | 2 | Wondolowski, Opara | ||
| Revolution | 0 | |||||
| 17/04/2010 | Carson | Galaxy | 2 | Buddle (2) | ||
| Real Salt Lake | 1 | Beckerman | ||||
| 18/04/2010 | Commerce City | Rapids | 3 | Casey (2P), Larentowicz | ||
| Toronto | 1 | De Rosario (P) | ||||
| 5ª Semana | ||||||
| 22/04/2010 | Frisco | Dallas | 2 | Cunningham (2P) | ||
| Sounders | 2 | Zakuani, Montero | ||||
| 24/04/2010 | New York | Red Bulls | 2 | Salou, Angel (P) | ||
| Union | 1 | Le Toux | ||||
| 24/04/2010 | Columbus | Crew | 1 | Barros Schelotto (P) | ||
| Real Salt Lake | 0 | |||||
| 24/04/2010 | Foxborough | Revolution | 1 | Perovic | ||
| Rapids | 2 | Ballouchy, Mastroeni | ||||
| 24/04/2010 | Bridgeview | Fire | 2 | Husidie, Lowry | ||
| Dynamo | 0 | |||||
| 24/04/2010 | Kansas City | Wizards | 0 | |||
| Galaxy | 0 | |||||
| 24/04/2010 | Carson | Chivas USA | 3 | Kljestan, Braun, Chijindu | ||
| Earthquakes | 2 | Wondolowski (P), Beitashour | ||||
| 25/04/2010 | Toronto | Toronto | 2 | De Rosario, White | ||
| Sounders | 0 | |||||
| 6ª Semana | ||||||
| 01/05/2010 | Washington | DC United | 0 | |||
| Red Bulls | 2 | Salou, Angel | ||||
| 01/05/2010 | Foxborough | Revolution | 1 | Schilawski | ||
| Dallas | 1 | Harris | ||||
| 01/05/2010 | Bridgeview | Fire | 1 | Husidic | ||
| Chivas USA | 1 | Maicon Santos | ||||
| 01/05/2010 | Houston | Dynamo | 3 | Landin, Mullan, Appiah | ||
| Wizards | 0 | |||||
| 01/05/2010 | Seattle | Sounders | 1 | Zakuani | ||
| Crew | 1 | Lenhart | ||||
| 01/05/2010 | Sandy | Real Salt Lake | 2 | Olave, Williams | ||
| Toronto | 1 | De Rosario (P) | ||||
| 01/05/2010 | Santa Clara | Earthquakes | 1 | Wondolowski | ||
| Rapids | 0 | |||||
| 01/05/2010 | Carson | Galaxy | 3 | DelaGarza, Buddle (2) | ||
| Union | 1 | McInerney | ||||
| 7ª Semana | ||||||
| 05/05/2010 | Washington | DC United | 2 | Allsopp (2) | ||
| Wizards | 1 | Kamara | ||||
| 05/05/2010 | Foxborough | Revolution | 0 | |||
| Chivas USA | 4 | Padilla (2), Braun, Gavin | ||||
| 05/05/2010 | Houston | Dynamo | 0 | |||
| Dallas | 1 | Ihemelu | ||||
| 05/05/2010 | Commerce City | Rapids | 0 | |||
| Galaxy | 1 | Gordon | ||||
| 08/05/2010 | Sandy | Real Salt Lake | 3 | Beckerman, Olave, Saborio | ||
| Union | 0 | |||||
| 08/05/2010 | Seattle | Sounders | 0 | |||
| Galaxy | 4 | Kirovski, Gonzalez, Dunivant, Donovan | ||||
| 08/05/2010 | Toronto | Toronto | 4 | LaBrocca, White, Barrett (2) | ||
| Fire | 1 | Pause | ||||
| 08/05/2010 | Columbus | Crew | 3 | Gaven, Gibbs (A), Rogers | ||
| Revolution | 2 | Boggs (2) | ||||
| 08/05/2010 | Frisco | Dallas | 1 | Cunningham | ||
| DC United | 0 | |||||
| 08/05/2010 | Santa Clara | Earthquakes | 4 | Johnson, Gjertsen, Wondolowski, Burling | ||
| Red Bulls | 0 | |||||
| 08/05/2010 | Carson | Chivas USA | 0 | |||
| Dynamo | 2 | Davis, Serioux | ||||
| 8ª Semana | ||||||
| 13/05/2010 | Sandy | Real Salt Lake | 3 | Findley, Saborio (2) | ||
| Houston | 1 | Mullan | ||||
| 15/05/2010 | Philadelphia | Union | 1 | Mwanga | ||
| Dallas | 1 | Shea | ||||
| 15/05/2010 | Foxborough | Revolution | 0 | |||
| Earthquakes | 0 | |||||
| 15/05/2010 | Columbus | Crew | 1 | Barros Schelotto (P) | ||
| Chivas USA | 0 | |||||
| 15/05/2010 | Washington | DC United | 0 | |||
| Rapids | 1 | Ballouchy | ||||
| 15/05/2010 | New York | Red Bulls | 0 | |||
| Sounders | 1 | Montero | ||||
| 15/05/2010 | Kansas City | Wizards | 2 | Kamara (2) | ||
| Fire | 2 | Martinez, McBride | ||||
| 15/05/2010 | Carson | Galaxy | 0 | |||
| Toronto | 0 | |||||
| 08/05/2010 | Frisco | Dallas | 1 | Cunningham | ||
| DC United | 0 | |||||
| 08/05/2010 | Santa Clara | Earthquakes | 4 | Johnson, Gjertsen, Wondolowski, Burling | ||
| Red Bulls | 0 | |||||
| 08/05/2010 | Carson | Chivas USA | 0 | |||
| Dynamo | 2 | Davis, Serioux | ||||
| 9ª Semana | ||||||
| 20/05/2010 | New York | Red Bulls | 1 | Tchani | ||
| Crew | 3 | Gaven, Iro, Renteria | ||||
| 20/05/2010 | Frisco | Dallas | 0 | |||
| Galaxy | 1 | Magee | ||||
| 22/05/2010 | Carson | Chivas USA | 1 | Braun | ||
| Real Salt Lake | 2 | Wingert, Espindola | ||||
| 22/05/2010 | Toronto | Toronto | 1 | Barrett | ||
| Revolution | 0 | |||||
| 22/05/2010 | Seattle | Sounders | 0 | |||
| Earthquakes | 1 | Wondolowski | ||||
| 22/05/2010 | Houston | Dynamo | 2 | Cruz, Oduro | ||
| DC United | 0 | |||||
| 23/05/2010 | Kansas City | Wizards | 0 | |||
| Crew | 1 | Renteria | ||||
| 10ª Semana | ||||||
| 27/05/2010 | Bridgeview | Fire | 1 | McBride | ||
| Dallas | 1 | Ferreira | ||||
| 29/05/2010 | Columbus | Crew | 0 | |||
| Galaxy | 2 | Stephens, Bowen | ||||
| 29/05/2010 | Washington | DC United | 3 | Najar, Cristman, Talley (P) | ||
| Chivas | 2 | Braun, Galindo | ||||
| 29/05/2010 | Foxborough | Revoluton | 3 | Perovic, Ream (A), Schilawski | ||
| Red Bulls | 2 | Stammler, Angel | ||||
| 29/05/2010 | Houston | Dynamo | 2 | Ching, Robinson | ||
| Union | 3 | Salinas, Le Toux, Mwanga | ||||
| 29/05/2010 | Commerce City | Rapids | 1 | Casey | ||
| Sounders | 0 | |||||
| 29/05/2010 | Sandy | Real Salt Lake | 4 | Espindola, Saborio, Russell, Grabavoy | ||
| Wizards | 1 | Wolff | ||||
| 29/05/2010 | Santa Clara | Earthquakes | 1 | Corrales | ||
| Toronto | 3 | Barrett, De Rosario (2) | ||||
| 11ª Semana | ||||||
| 02/06/2010 | New York | Red Bulls | 2 | Ubiparipovic, Angel | ||
| Dynamo | 1 | Ching, Robinson | ||||
| 02/06/2010 | Santa Clara | Earthquakes | 2 | Alvarez, Wondolowski | ||
| Crew | 2 | Gaven, Marshall | ||||
| 05/06/2010 | Toronto | Toronto | 0 | |||
| Kansas City | 0 | |||||
| 05/06/2010 | Washington | DC United | 0 | |||
| Real Salt Lake | 0 | |||||
| 05/06/2010 | New York | Red Bulls | 1 | Stammler | ||
| Chivas USA | 0 | |||||
| 05/06/2010 | Carson | Galaxy | 4 | |||
| Houston | 1 | |||||
| 05/06/2010 | Bridgeview | Fire | 2 | Husidic, Pappa | ||
| Union | 1 | Mwanga | ||||
| 05/06/2010 | Frisco | Dallas | 2 | Shea (2) | ||
| Earthquakes | 0 | |||||
| 05/06/2010 | Commerce City | Rapids | 1 | Moor | ||
| Crew | 0 | |||||
| 05/06/2010 | Seattle | Sounders | 3 | Arce, Zakuani, Montero | ||
| Revolution | 0 | |||||
| 12ª Semana | ||||||
| 09/06/2010 | Bdrigeview | Fire | 2 | Pappa (2) | ||
| Rapids | 2 | Cummings, Casey | ||||
| 09/06/2010 | Sandy | Real Salt Lake | 1 | Morales | ||
| Galaxy | 0 | |||||
| 10/06/2010 | Kansas City | Wizards | 2 | Kamara, Zusi | ||
| Union | 0 | |||||
| 10/06/2010 | Seattle | Sounders | 2 | Riley, Montero | ||
| DC United | 3 | Pontius (3) | ||||
| 13ª Semana | ||||||
| 25/06/2010 | Sandy | Real Salt Lake | 0 | |||
| Earthquakes | 0 | |||||
| 26/06/2010 | Columbus | Crew | 2 | Barros Schelotto, Brunner | ||
| DC United | 0 | |||||
| 26/06/2010 | Toronto | Toronto | 0 | |||
| Galaxy | 0 | |||||
| 26/06/2010 | Houston | Dynamo | 2 | Cruz, Ngwenya | ||
| Rapids | 2 | Casey, Palmer (A) | ||||
| 26/06/2010 | Kansas City | Wizards | 0 | |||
| Red Bulls | 3 | Salou, Angel (2) | ||||
| 26/06/2010 | Carson | Chivas USA | 1 | Romero | ||
| Dallas | 2 | Jazic (A), Ferreira (P) | ||||
| 27/06/2010 | Philadelphia | Union | 3 | Le Toux (P), Fred, Mwanga | ||
| Sounders | 1 | Noonan | ||||
| 27/06/2010 | Foxborough | Revolution | 0 | |||
| Fire | 1 | Pappa | ||||
| 14ª Semana | ||||||
| 01/07/2010 | Toronto | Toronto | 1 | Gargan | ||
| Houston | 1 | Ching | ||||
| 02/07/2010 | Sandy | Real Salt Lake | 5 | Espindola, Olave, Saborio (2), Findley | ||
| Revolution | 0 | |||||
| 03/07/2010 | Columbus | Crew | 2 | Moffat, Garey | ||
| Fire | 1 | Hejduk (A) | ||||
| 03/07/2010 | Frisco | Dallas | 1 | Ferreira (P) | ||
| Kansas City | 0 | |||||
| 03/07/2010 | Santa Clara | Eartquakes | 1 | Opara | ||
| DC United | 1 | Najar | ||||
| 03/07/2010 | Carson | Chivas USA | 1 | Gavin | ||
| Union | 1 | Mwanga | ||||
| 04/07/2010 | Commerce City | Rapids | 1 | Cummings | ||
| Red Bulls | 1 | Angel | ||||
| 04/07/2010 | Carson | Galaxy | 3 | Buddle, Vitor Junior, Riley (A) | ||
| Sounders | 1 | Zakuani | ||||
| 15ª Semana | ||||||
| 08/07/2010 | Bridgeview | Fire | 0 | |||
| Real Salt Lake | 1 | Findley (P) | ||||
| 10/07/2010 | Toronto | Toronto | 1 | Ibrahim | ||
| Rapids | 0 | |||||
| 10/07/2010 | Philadelphia | Union | 1 | Fred | ||
| Eartquakes | 2 | Glen, Alvarez | ||||
| 10/07/2010 | Foxborough | Revolution | 2 | Perovic, Dube | ||
| Galaxy | 0 | |||||
| 10/07/2010 | New York | Red Bulls | 0 | |||
| DC United | 0 | |||||
| 10/07/2010 | Houston | Dynamo | 0 | |||
| Crew | 0 | |||||
| 10/07/2010 | Kansas City | Wizards | 0 | |||
| Chivas USA | 2 | Braun (2) | ||||
| 11/07/2010 | Seattle | Sounders | 1 | Montero | ||
| Dallas | 1 | Ferreira | ||||
| 16ª Semana | ||||||
| 14/07/2010 | Columbus | Crew | 0 | |||
| Wizards | 1 | Bunbury | ||||
| 15/07/2010 | Washington | DC United | 0 | |||
| Sounders | 1 | Levesque | ||||
| 17/07/2010 | Philadelphia | Union | 2 | Orozco, Le Toux (P) | ||
| Toronto | 1 | Barrett | ||||
| 17/07/2010 | Columbus | Crew | 2 | Renteria, Carroll | ||
| New York | 0 | |||||
| 17/07/2010 | Frisco | Dallas | 2 | Shea, Harris | ||
| Real Salt Lake | 0 | |||||
| 17/07/2010 | Commerce City | Rapids | 1 | Casey | ||
| Wizards | 1 | Arnaud | ||||
| 18/07/2010 | Washington | DC United | 1 | Najar | ||
| Galaxy | 2 | Buddle, Donovan (P) | ||||
| 17ª Semana | ||||||
| 22/07/2010 | Carson | Galaxy | 2 | Buddle, Donovan (P) | ||
| Earthquakes | 2 | Convey, McDonald | ||||
| 24/07/2010 | Toronto | Toronto | 1 | Santos | ||
| Dallas | 1 | Rodriguez | ||||
| 24/07/2010 | Columbus | Crew | 3 | Renteria, Iro, Griffit | ||
| Houston | 0 | |||||
| 24/07/2010 | Sandy | Real Salt Lake | 1 | Grabavoy | ||
| Chivas USA | 1 | Cisneros | ||||
| 25/07/2010 | Seattle | Sounders | 2 | Zakuani (2) | ||
| Rapids | 1 | Cummings | ||||
| 18ª Semana | ||||||
| 31/07/2010 | Philadelphia | Union | 1 | Le Toux | ||
| Revolution | 1 | Perovic | ||||
| 31/07/2010 | Commerce City | Rapids | 1 | Ballouchy (P) | ||
| Dallas | 1 | Baudet (A) | ||||
| 31/07/2010 | Houston | Dynamo | 2 | Davis (P), Mullan | ||
| Red Bulls | 2 | Angel (2) | ||||
| 31/07/2010 | Kansas City | Wizards | 1 | Bunbury | ||
| Toronto | 0 | |||||
| 31/07/2010 | Sandy | Real Salt Lake | 3 | Saborio, Findley, Gonzalez | ||
| DC United | 0 | |||||
| 31/07/2010 | Santa Clara | Earthquakes | 0 | |||
| Sounders | 1 | Montero | ||||
| 31/07/2010 | Carson | Chivas USA | 3 | Braun, Gavin, Borja | ||
| Crew | 1 | Lenhart | ||||
| 01/08/2010 | Carson | Galaxy | 2 | Donovan (2P) | ||
| Fire | 3 | Pappa, John, Banner | ||||
| 19ª Semana | ||||||
| 05/08/2010 | Philadelphia | Union | 1 | Le Toux (P) | ||
| Crew | 2 | Lenhart (2) | ||||
| 07/08/2010 | Toronto | Toronto | 2 | Attakora-Gyan, Barrett | ||
| Chivas USA | 1 | Maldonado (P) | ||||
| 07/08/2010 | Foxborough | Revolution | 1 | Phelan | ||
| DC UNited | 0 | |||||
| 07/08/2010 | Kansas City | Wizards | 1 | Kamara | ||
| Real Salt Lake | 1 | Findley | ||||
| 07/08/2010 | Commerce City | Rapids | 1 | Busch (A) | ||
| Earthquakes | 0 | |||||
| 08/08/2010 | Frisco | Dallas | 3 | Ferreira (P), Cunningham (2) | ||
| Union | 1 | Moreno | ||||
| 08/08/2010 | Bridgeview | Fire | 0 | |||
| Red Bulls | 0 | |||||
| 08/08/2010 | Sounders | Seattle | 2 | Montero, Fernandez | ||
| Dynamo | 0 | |||||
| 20ª Semana | ||||||
| 11/08/2010 | New York | Red Bulls | 1 | Lindpere | ||
| Toronto | 0 | |||||
| 11/08/2010 | Philadelphia | Union | 1 | Mwanga | ||
| Real Salt Lake | 1 | Espindola | ||||
| 14/08/2010 | Philadelphia | Union | 1 | Mwanga | ||
| Rapids | 1 | Larenttowicz | ||||
| 14/08/2010 | New York | Red Bulls | 0 | |||
| Galaxy | 1 | Buddle | ||||
| 14/08/2010 | Washington | DC United | 1 | Benitez (A) | ||
| Dallas | 3 | Ferreira, Alexander, Cunningham | ||||
| 14/08/2010 | Foxborough | Revolution | 1 | Stolica | ||
| Houston | 0 | |||||
| 14/08/2010 | Sandy | Real Salt Lake | 2 | Morales (2) | ||
| Crew | 0 | |||||
| 14/08/2010 | Santa Clara | Earthquakes | 1 | Wondolowski | ||
| Wizards | 0 | |||||
| 14/08/2010 | Carson | Chivas USA | 0 | |||
| Sounders | 0 | |||||
| 21ª Semana | ||||||
| 18/08/2010 | Bridgeview | Chicago | 2 | Husidic, Carr | ||
| Revolution | 1 | Perovic | ||||
| 21/08/2010 | Toronto | Toronto | 1 | De Rosario | ||
| Red Bulls | 4 | Marquez, Joseph (A), Angel (P), Robinson | ||||
| 21/08/2010 | Santa Clara | Earthquakes | 1 | Wondolowski | ||
| Galaxy | 0 | |||||
| 21/08/2010 | Columbus | Crew | 3 | Barros Schelotto (P), Garey, Lenhart | ||
| Rapids | 1 | Mastroeni | ||||
| 21/08/2010 | Frisco | Dallas | 1 | Shea | ||
| Chivas USA | 0 | |||||
| 21/08/2010 | Houston | Dynamo | 4 | Ching (3), Palmer | ||
| Chicago | 3 | Carr, Boswell (A), Conde | ||||
| 21/08/2010 | Kansas City | Wizards | 4 | Diop (2), Kamara, Jewsbury | ||
| Revolution | 1 | Mansally | ||||
| 22/08/2010 | Washington | DC United | 2 | Allsopp (2) | ||
| Union | 0 | |||||
| 22ª Semana | ||||||
| 28/08/2010 | Columbus | Crew | 0 | |||
| Dallas | 0 | |||||
| 28/08/2010 | Toronto | Toronto | 0 | |||
| Real Salt Lake | 0 | |||||
| 28/08/2010 | Foxborough | Revolution | 1 | Stolica | ||
| Union | 2 | McInerney, Mapp | ||||
| 28/08/2010 | New York | Red Bulls | 2 | Richards, Henry | ||
| Earthquakes | 0 | |||||
| 28/08/2010 | Commerce City | Rapids | 3 | Smith, Cummings, Casey | ||
| Dynamo | 0 | |||||
| 28/08/2010 | Carson | Galaxy | 0 | |||
| Wizards | 2 | Arnaud, Conrad | ||||
| 28/08/2010 | Seattle | Sounders | 2 | Montero (2) | ||
| Fire | 1 | Thorrington (P) | ||||
| 29/08/2010 | Carson | Chivas USA | 1 | Braun | ||
| DC United | 0 | |||||
| 23ª Semana | ||||||
| 04/09/2010 | Philadelphia | Union | 1 | Le Toux | ||
| Wizards | 1 | Arnaud | ||||
| 04/09/2010 | Bridgeview | Fire | 1 | John | ||
| Galaxy | 1 | Gonzalez | ||||
| 04/09/2010 | Washington | DC United | 0 | |||
| Crew | 1 | Barros Schelotto | ||||
| 04/09/2010 | Foxborough | Revolution | 3 | Tierney, Perovic, Dube | ||
| Sounders | 1 | Zakuani | ||||
| 04/09/2010 | Frisco | Dallas | 1 | Cunningham | ||
| Toronto | 0 | |||||
| 04/09/2010 | Commerce City | Rapids | 3 | Casey, Cummings (2) | ||
| Chivas USA | 0 | |||||
| 04/09/2010 | Sandy | Real Salt Lake | 1 | Espindola | ||
| Red Bulls | 0 | |||||
| 05/09/2010 | Houston | Dynamo | 1 | Davis | ||
| Earthquakes | 2 | Stephenson, Deiberson | ||||
| 24ª Semana | ||||||
| 08/09/2010 | Bridgeview | Fire | 0 | |||
| Toronto | 0 | |||||
| 09/09/2010 | Seattle | Sounders | 0 | |||
| Real Salt Lake | 0 | |||||
| 10/09/2010 | Carson | Chivas USA | 2 | Braun, Nagamura | ||
| Revolution | 0 | |||||
| 11/09/2010 | New York | Red Bulls | 3 | Henry, Ream, Richards | ||
| Rapids | 1 | Cummings | ||||
| 11/09/2010 | Toronto | Toronto | 0 | |||
| DC United | 1 | James | ||||
| 11/09/2010 | Philadelphia | Union | 1 | Le Toux | ||
| Fire | 0 | |||||
| 11/09/2010 | Santa Clara | Earthquakes | 0 | |||
| Dallas | 0 | |||||
| 11/09/2010 | Carson | Galaxy | 3 | Buddle, Kovalenko, Kirovski | ||
| Crew | 1 | Mendoza | ||||
| 25ª Semana | ||||||
| 15/09/2010 | Santa Clara | Earthquakes | 1 | Wondolowski | ||
| Union | 0 | |||||
| 16/09/2010 | Frisco | Dallas | 2 | Rodriguez, Alexander | ||
| Red Bulls | 2 | Ballouchy, Benitez (A) | ||||
| 18/09/2010 | Sandy | Real Salt Lake | 1 | Saborio (P) | ||
| Chicago | 0 | |||||
| 18/09/2010 | Columbus | Crew | 0 | |||
| Sounders | 4 | Nkufo (3), Sturgis (P) | ||||
| 18/09/2010 | Houston | Dynamo | 1 | Ching | ||
| Toronto | 2 | De Rosario (2) | ||||
| 18/09/2010 | Commerce City | Rapids | 3 | Cummings, Casey, Thompson | ||
| Revolution | 0 | |||||
| 18/09/2010 | Carson | Galaxy | 2 | Donovan (2) | ||
| DC United | 1 | Najar | ||||
| 19/09/2010 | Carson | Chivas USA | 0 | |||
| Wizards | 2 | Kamara, Bunbury | ||||
| 26ª Semana | ||||||
| 22/09/2010 | Kansas City | Wizards | 4 | Kamara, Bunbury, Serioux (A), Wolff | ||
| Dynamo | 3 | Weaver, Oduro, Serioux | ||||
| 22/09/2010 | Frisco | Dallas | 2 | Ferreira (P), Cunningham | ||
| Revolution | 2 | Jospeh, Stolica | ||||
| 24/09/2010 | Carson | Galaxy | 0 | |||
| Red Bulls | 2 | Richards, Angel (P) | ||||
| 25/09/2010 | Philadelphia | Union | 3 | Morneo, Fred, Le Toux | ||
| Chivas USA | 0 | |||||
| 25/09/2010 | Toronto | Toronto | 2 | De Rosario, Maicon Santos | ||
| Earthquakes | 3 | Wondolowski (3, 1P) | ||||
| 25/09/2010 | Washington | DC United | 1 | Najar | ||
| Dynamo | 3 | McTavish (A), Cameron, Oduro | ||||
| 25/09/2010 | Foxborough | Revolution | 2 | Phelan, Joseph (P) | ||
| Crew | 2 | Gibbs (A), Barros Schelotto (P) | ||||
| 25/09/2010 | Bridgeview | Fire | 0 | |||
| Sounders | 1 | Nkufo | ||||
| 25/09/2010 | Kansas City | Wizards | 1 | Smith | ||
| Dallas | 3 | Chavez, Rodriguez, Cunningham | ||||
| 25/09/2010 | Sandy | Real Salt Lake | 1 | Borchers | ||
| Rapids | 1 | Casey | ||||
| 27ª Semana | ||||||
| 29/09/2010 | Commerce City | Rapids | 4 | Cummings (2), Thompson, Amarikwa | ||
| Union | 1 | McInerney | ||||
| 29/09/2010 | Santa Clara | Earthquakes | 0 | |||
| Fire | 3 | Kinney, Ljungberg, Nyarko | ||||
| 02/10/2010 | Seattle | Sounders | 3 | Zakuani, Nkufo, Nyassi | ||
| Toronto | 2 | De Rosario, Barrett | ||||
| 02/10/2010 | Philadelphia | Union | 1 | Le Toux | ||
| Dynamo | 1 | Hainault | ||||
| 02/10/2010 | Columbus | Crew | 0 | |||
| Earthquakes | 0 | |||||
| 02/10/2010 | Foxborough | Revolution | 1 | Mansally | ||
| Real Salt Lake | 2 | Borchers, Saborio | ||||
| 02/10/2010 | New York | Red Bulls | 1 | Richards | ||
| Wizards | 0 | |||||
| 02/10/2010 | Frisco | Dallas | 3 | Rodriguez, Chavez, Cunningham (P) | ||
| Fire | 0 | |||||
| 02/10/2010 | Commerce City | Rapids | 0 | |||
| DC United | 1 | Allsopp | ||||
| 03/10/2010 | Carson | Chivas USA | 1 | Gordon | ||
| Galaxy | 2 | Buddle, Beckham | ||||
| 28ª Semana | ||||||
| 07/10/2010 | Philadelphia | Union | 0 | |||
| Galaxy | 1 | Buddle | ||||
| 08/10/2010 | Bridgeview | Fire | 2 | Lowry, McBride | ||
| Crew | 0 | |||||
| 09/10/2010 | New York | Red Bulls | 0 | |||
| Real Salt Lake | 0 | |||||
| 09/10/2010 | Frisco | Dallas | 2 | Rodriguez, Ferreira | ||
| Rapids | 2 | Larentowicz (2) | ||||
| 09/10/2010 | Washington | DC United | 0 | |||
| Earthquakes | 2 | Wondolowski (2) | ||||
| 09/10/2010 | Kansas City | Wizards | 1 | Arnaud (P) | ||
| Sounders | 2 | Nyassi, Fernandez | ||||
| 09/10/2010 | Carson | Chivas USA | 3 | Flores, Padilla, Espinoza | ||
| Toronto | 0 | |||||
| 10/10/2010 | Houston | Dynamo | 1 | Oduro | ||
| Revolution | 2 | Joseph, Dube | ||||
| 29ª Semana | ||||||
| 12/10/2010 | Bridgeview | Fire | 0 | |||
| Wizards | 2 | Arnaud, Bunbury | ||||
| 08/10/2010 | Bridgeview | Fire | 2 | Lowry, McBride | ||
| Crew | 0 | |||||
| 09/10/2010 | New York | Red Bulls | 0 | |||
| Real Salt Lake | 0 | |||||
| 09/10/2010 | Frisco | Dallas | 2 | Rodriguez, Ferreira | ||
| Rapids | 2 | Larentowicz (2) | ||||
| 09/10/2010 | Washington | DC United | 0 | |||
| Earthquakes | 2 | Wondolowski (2) | ||||
| 09/10/2010 | Kansas City | Wizards | 1 | Arnaud (P) | ||
| Sounders | 2 | Nyassi, Fernandez | ||||
| 09/10/2010 | Carson | Chivas USA | 3 | Flores, Padilla, Espinoza | ||
| Toronto | 0 | |||||
| 10/10/2010 | Houston | Dynamo | 1 | Oduro | ||
| Revolution | 2 | Joseph, Dube | ||||
| 30ª Semana | ||||||
| 15/10/2010 | Seattle | Sounders | 2 | Zakuani, Alonso | ||
| Chivas USA | 1 | Padilla | ||||
| 16/10/2010 | Bridgeview | Toronto | 2 | Santos, Peterson | ||
| Crew | 2 | Marshall, Hesmer | ||||
| 16/10/2010 | Philadelphia | Union | 0 | Fred, Orozco | ||
| Red Bulls | 1 | Borman | ||||
| 16/10/2010 | Foxborough | Revolution | 1 | Joseph | ||
| Wizards | 0 | |||||
| 16/10/2010 | Sandy | Real Salt Lake | 2 | Gravaboy, Morales | ||
| Dallas | 0 | |||||
| 16/10/2010 | Santa Clara | Earthquakes | 0 | |||
| Dynamo | 1 | Hainault | ||||
| 16/10/2010 | Carson | Galaxy | 1 | Buddle | ||
| Rapids | 3 | Vitor Junior (A), Casey, Cummings | ||||
| 31ª Semana | ||||||
| 20/10/2010 | Santa Clara | Eartquakes | 3 | Wondolowski (3, 1P) | ||
| Chivas USA | 0 | |||||
| 21/10/2010 | New York | Red Bulls | 2 | Richards, Lindpere | ||
| Revolution | 0 | |||||
| 23/10/2010 | Houston | Dynamo | 2 | Cameron, Weaver | ||
| Sounders | 1 | Riley | ||||
| 23/10/2010 | Washington | DC United | 2 | Quaranta, Moreno | ||
| Toronto | 3 | Santos, De Rosario (2) | ||||
| 23/10/2010 | Kansas City | Wizards | 4 | Diop (3), Da Silva (A) | ||
| Eartquakes | 1 | Wondolowski | ||||
| 23/10/2010 | Colorado | Crew | 2 | Cummings, Casey | ||
| Real Salt Lake | 2 | Saborio (2, 1P) | ||||
| 23/10/2010 | Carson | Chivas USA | 1 | Maldonado | ||
| Fire | 4 | McBride, Ljungberg, Carr, Husidie | ||||
| 24/10/2010 | Columbus | Crew | 3 | Barros Schelotto (P), Renteria, Mendoza | ||
| Philadelphia | 1 | Le Toux | ||||
| 24/10/2010 | Carson | Galaxy | 2 | Beckham, Vitor Junior | ||
| Dallas | 1 | Le Toux | ||||
| Playoffs | ||||||
| Semifinales de Conferencia | ||||||
| 28/10/2010 | Commerce City | Rapids | 1 | Mastroeni | ||
| Crew | 0 | |||||
| 06/11/2010 | Columbus | Crew | 2(4) | Gaven, Rogers | ||
| Rapids | 1(5) | Casey | ||||
| 30/10/2010 | Frisco | Dallas | 2 | Cunningham, Avila | ||
| Real Salt Lake | 1 | Espindola | ||||
| 06/11/2010 | Sandy | Real Salt Lake | 1 | Findley | ||
| Dallas | 1 | McCarty | ||||
| 30/10/2010 | Santa Clara | Earthquakes | 0 | |||
| Red Bulls | 1 | Lindpere | ||||
| 04/11/2010 | New York | Red Bulls | 1 | Angel | ||
| Earthquakes | 3 | Convey (2), Woldolowski | ||||
| 31/10/2010 | Seattle | Sounders | 0 | |||
| Galaxy | 1 | Buddle | ||||
| 07/11/2010 | Carson | Galaxy | 2 | Buddle, Gonzalez | ||
| Sounders | 1 | Zakuani | ||||
| Finales de Conferencia | ||||||
| 13/11/2010 | Commerce City | Rapids | 1 | Kimura | ||
| Earthquakes | 0 | |||||
| 14/11/2010 | Carson | Galaxy | 0 | |||
| Dallas | 3 | Ferreira, John, Chavez | ||||
| Final MLS | ||||||
| 21/11/2010 | Toronto | Rapids | 2 | Casey, John (A) | ||
| Dallas | 1 | Ferreira | ||||