| GOLEADORES CAMPEONATO DE 2ª DIVISION 2022 | ||
| Goles | Jugador | Equipo |
| 12 | Bairon Monroy | San Marcos |
| 10 | Leandro Ruiz | Real San Joaquin |
| 9 | Diego Cuellar | Lautaro |
| 8 | Jose Luis Silva | Lautaro |
| 8 | Hernan Ramirez | Limache |
| 7 | Ignacio Pinilla | Iberia |
| 7 | Diego Vallejos | Independiente |
| 6 | Nicolas Barrera | Real San Joaquin |
| 6 | Nahuel Donadell | San Marcos |
| 5 | Matias Villablanca | General Velasquez |
| 5 | David Quiroz | Rodelindo Roman |
| 5 | Sergio Riffo | San Antonio |
| 4 | Alvaro Lopez | General Velasquez |
| 4 | Kevin Serrano | General Velasquez |
| 4 | Augustine Ezeali | Rodelindo Roman |
| 4 | Nicolas Silva | Rodelindo Roman |
| 4 | Brian Leiva | San Antonio |
| 4 | Rodrigo Auzmendi | San Marcos |
| 4 | Cristian Gonzalez | Valdivia |
| 4 | Guillermo Avello | Valdivia |
| 4 | Xabier Santos | Valdivia |
| 3 | Alexander Bolaños | Concepcion |
| 3 | Cristobal Vargas | Concepcion |
| 3 | Juan Sebastian Ibarra | Concepcion |
| 3 | Hugo Herrera | General Velasquez |
| 3 | Tomas Pino | General Velasquez |
| 3 | Fabian Neira | Independiente |
| 3 | Javier Guzman | Independiente |
| 3 | Rene Melendez | Lautaro |
| 3 | Hugo Toro | Limache |
| 3 | Nicolas Muñoz | Limache |
| 3 | Alessandro Rizzoli | Rodelindo Roman |
| 3 | Luis Salazar | Rodelindo Roman |
| 3 | Gonzalo Aban | San Antonio |
| 3 | Luciano Diaz | San Antonio |
| 3 | Rodrigo Gattas | San Antonio |
| 3 | Cristian Valenzuela | San Marcos |
| 3 | Bastian Araya | Trasandino |
| 3 | Joaquin Llanos | Trasandino |
| 3 | Jose Tomas Arancibia | Trasandino |
| 3 | Lucas Simon | Trasandino |
| 3 | Nicolas Forttes | Trasandino |
| 3 | Carlos Pavez | Valdivia |
| 3 | Gabriel Harding | Valdivia |
| 2 | Gabriel Vargas | Concepcion |
| 2 | Ignacio Sepulveda | Concepcion |
| 2 | Lautaro Rigazzi | Concepcion |
| 2 | Jorge Uribe | General Velasquez |
| 2 | Patricio Troncoso | General Velasquez |
| 2 | Erick Millalen | Iberia |
| 2 | Ignacio Contreras | Iberia |
| 2 | Luis Oyarzo | Iberia |
| 2 | Alex Diaz | Independiente |
| 2 | Felipe Escobar | Independiente |
| 2 | Misael Llanten | Lautaro |
| 2 | Nicolas Gutierrez | Lautaro |
| 2 | Nicolas Solabarrieta | Lautaro |
| 2 | Abel Herrera | Limache |
| 2 | Kevin Campillay | Real San Joaquin |
| 2 | Luciano Meneses | Real San Joaquin |
| 2 | Bayron Saavedra | Rodelindo Roman |
| 2 | Nicolas Aravena | Rodelindo Roman |
| 2 | Flavio Rojas | San Antonio |
| 2 | Diego Ceron | San Marcos |
| 2 | Valentin Coria | San Marcos |
| 2 | Alberto Hernandez | Trasandino |
| 2 | Felipe Lee Chong | Trasandino |
| 2 | Wilson Martinez | Trasandino |
| 2 | Antonio Estrada | Valdivia |
| 2 | Emiliano Bonfigli | Valdivia |
| 2 | Nicolas Astete | Valdivia |
| 2 | Renato Araya | Valdivia |
| 1 | Cristofer Salas | Concepcion |
| 1 | Fabian Ramirez | Concepcion |
| 1 | Gerardo Navarrete | Concepcion |
| 1 | Joauqin Verdugo | Concepcion |
| 1 | Maximiliano Riveros | Concepcion |
| 1 | Daud Gazale | General Velasquez |
| 1 | Diego Salas | General Velasquez |
| 1 | Hernan Astudillo | General Velasquez |
| 1 | John Alegria | General Velasquez |
| 1 | Juan Tobar | General Velasquez |
| 1 | Fernando Quiroz | Iberia |
| 1 | Gabriel Castillo | Iberia |
| 1 | Marcelo Flores | Iberia |
| 1 | Matias Coronado | Iberia |
| 1 | Miguel Orellana | Iberia |
| 1 | Luciano Araya | Independiente |
| 1 | Matias Amestica | Independiente |
| 1 | Matias Pinto | Independiente |
| 1 | Carlos Toselli | Lautaro |
| 1 | Kevin Hidalgo | Lautaro |
| 1 | Matias Rozas | Lautaro |
| 1 | Benjamin Inostroza | Limache |
| 1 | Cristian Collao | Limache |
| 1 | Diego Guillermo Huerta | Limache |
| 1 | Elias Borrego | Limache |
| 1 | Hugo Rojo | Limache |
| 1 | Raul Bernal | Limache |
| 1 | Sebastian Romero | Limache |
| 1 | Alejandro Quiero | Real San Joaquin |
| 1 | Diego Figueroa | Real San Joaquin |
| 1 | Diego Silva | Real San Joaquin |
| 1 | Lucas Abarca | Real San Joaquin |
| 1 | Marcelo Carvajal | Real San Joaquin |
| 1 | Nelson Cordova | Real San Joaquin |
| 1 | Nicolas Guerra | Real San Joaquin |
| 1 | Santiago Salaberry | Real San Joaquin |
| 1 | Fabian Bustos | Rodelindo Roman |
| 1 | Jorge Lagues | Rodelindo Roman |
| 1 | Ramiro Galvez | Rodelindo Roman |
| 1 | Alexis Villarreal | San Antonio |
| 1 | Junio Lopes | San Antonio |
| 1 | Cristobal Guerra | San Marcos |
| 1 | Felipe Baez | San Marcos |
| 1 | Ignacio Mesias | San Marcos |
| 1 | Mauricio Arias | San Marcos |
| 1 | Mirko Serrano | San Marcos |
| 1 | Alejandro Rios | Trasandino |
| 1 | Alejandro Zuñiga | Trasandino |
| 1 | Douglas Estay | Trasandino |
| 1 | Fabrizio Tomarelli | Trasandino |
| 1 | Juan Segovia | Trasandino |
| 1 | Joel Martinez | Valdivia |
| 1 | John Jorquera | Valdivia |
| Autogoles | ||
| 1 | Jose Duarte | Real San Joaquin |
| 1 | Cegy Duran | Trasandino |